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Erythrocyte sedimentation rate during steady state, painful crisis and infection in children with sickle cell disease.
Saudi Med J. 2000 May; 21(5):461-3.SM

Abstract

OBJECTIVE

To evaluate Erythrocyte Sedimentation Rate in children with sickle cell disease.

METHODS

Erythrocyte Sedimentation Rate was performed in 95 children with sickle cell disease during the period from December 1992 to June 1999. Patients were classified into 4 groups. Patients in the steady state (group 1), painful crisis (group 2), mild infection (group 3) and moderate/severe infection (group 4). Comparison between the groups was performed using ANOVA and ANCOVA.

RESULTS

There were 55 males (58%) and 40 females (42%) with a mean age of 79.1 months. The mean Erythrocyte Sedimentation Rate values for the various groups were as follows: Group 1 (n=10); mean Erythrocyte Sedimentation Rate is 5 mm/hr (+/-4.6) and was significantly the lowest (p<0.05), group 2 (n=44); mean Erythrocyte Sedimentation Rate is 25.8 mm/hr (+/-16.3), group 3 (n=18); mean Erythrocyte Sedimentation Rate is 28.1 mm/hr (+/-25.8), while group 4 (n=23); mean Erythrocyte Sedimentation Rate is 99.2 mm/hr (+/-33.5) and was significantly the highest (p<0.05). Two cut-off values for the Erythrocyte Sedimentation Rate (> or = 30 mm/hr then > or = 50 mm/hr) were considered to evaluate their specificity and sensitivity for moderate/severe infection.

CONCLUSION

Although the Erythrocyte Sedimentation Rate is low in sickle cell disease, it does increase during painful crisis and infection and it is a useful indicator of moderate/severe infection.

Authors+Show Affiliations

Department of Child Health, College of Medicine and Medical Sciences, King Khalid Unviersity, PO Box 641, Abha, Kingdom of Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Validation Study

Language

eng

PubMed ID

11500681

Citation

Ahmed, Y F., et al. "Erythrocyte Sedimentation Rate During Steady State, Painful Crisis and Infection in Children With Sickle Cell Disease." Saudi Medical Journal, vol. 21, no. 5, 2000, pp. 461-3.
Ahmed YF, Abbag FI, Al-Qahtani JM, et al. Erythrocyte sedimentation rate during steady state, painful crisis and infection in children with sickle cell disease. Saudi Med J. 2000;21(5):461-3.
Ahmed, Y. F., Abbag, F. I., Al-Qahtani, J. M., Ghazali, B. M., & Abolfotouh, M. A. (2000). Erythrocyte sedimentation rate during steady state, painful crisis and infection in children with sickle cell disease. Saudi Medical Journal, 21(5), 461-3.
Ahmed YF, et al. Erythrocyte Sedimentation Rate During Steady State, Painful Crisis and Infection in Children With Sickle Cell Disease. Saudi Med J. 2000;21(5):461-3. PubMed PMID: 11500681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte sedimentation rate during steady state, painful crisis and infection in children with sickle cell disease. AU - Ahmed,Y F, AU - Abbag,F I, AU - Al-Qahtani,J M, AU - Ghazali,B M, AU - Abolfotouh,M A, PY - 2001/8/14/pubmed PY - 2001/9/14/medline PY - 2001/8/14/entrez SP - 461 EP - 3 JF - Saudi medical journal JO - Saudi Med J VL - 21 IS - 5 N2 - OBJECTIVE: To evaluate Erythrocyte Sedimentation Rate in children with sickle cell disease. METHODS: Erythrocyte Sedimentation Rate was performed in 95 children with sickle cell disease during the period from December 1992 to June 1999. Patients were classified into 4 groups. Patients in the steady state (group 1), painful crisis (group 2), mild infection (group 3) and moderate/severe infection (group 4). Comparison between the groups was performed using ANOVA and ANCOVA. RESULTS: There were 55 males (58%) and 40 females (42%) with a mean age of 79.1 months. The mean Erythrocyte Sedimentation Rate values for the various groups were as follows: Group 1 (n=10); mean Erythrocyte Sedimentation Rate is 5 mm/hr (+/-4.6) and was significantly the lowest (p<0.05), group 2 (n=44); mean Erythrocyte Sedimentation Rate is 25.8 mm/hr (+/-16.3), group 3 (n=18); mean Erythrocyte Sedimentation Rate is 28.1 mm/hr (+/-25.8), while group 4 (n=23); mean Erythrocyte Sedimentation Rate is 99.2 mm/hr (+/-33.5) and was significantly the highest (p<0.05). Two cut-off values for the Erythrocyte Sedimentation Rate (> or = 30 mm/hr then > or = 50 mm/hr) were considered to evaluate their specificity and sensitivity for moderate/severe infection. CONCLUSION: Although the Erythrocyte Sedimentation Rate is low in sickle cell disease, it does increase during painful crisis and infection and it is a useful indicator of moderate/severe infection. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/11500681/Erythrocyte_sedimentation_rate_during_steady_state_painful_crisis_and_infection_in_children_with_sickle_cell_disease_ L2 - http://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -