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Effect of endosulfan on antioxidants of freshwater fish Channa punctatus Bloch: 1. Protection against lipid peroxidation in liver by copper preexposure.
Arch Environ Contam Toxicol. 2001 Oct; 41(3):345-52.AE

Abstract

Effect of a single exposure of endosulfan (5 ppb) on catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and reduced glutathione (GSH) of liver, kidney, and gill of a freshwater fish (Channa punctatus Bloch) were evaluated after 24 h of treatment. Endosulfan exposure resulted in a significant induction (p < 0.05-0.001) of GPx, GST activity, and GSH levels in all the organs. However, CAT activity was found to be significantly decreased (p < 0.01-0.001). Lipid peroxidation (LPO) values were also determined in liver, kidney, and gill and a significant increase in LPO values (p < 0.05-0.01) was observed in all the organs. We also investigated whether preexposure to low concentration of copper (10 ppb) for 4 weeks has any protective effect against endosulfan-induced oxidative damage. In copper-acclimatized endosulfan-exposed fish, a significant decrease in GPx (p < 0.001), GST (p < 0.05), GSH (p < 0.001) levels, and LPO (p < 0.01) was observed in the liver, whereas CAT activity was increased significantly (p < 0.001). However, kidney and gill did not show any significant alterations in antioxidant levels. The results of this study demonstrate that endosulfan induces peroxidative damage in liver, kidney, and gill in response to which levels of antioxidant were modulated. However, when fish preacclimatized to copper were exposed to endosulfan, protection against oxidative damage was observed only in the liver. It is proposed that measurement of antioxidants in fish tissues may prove to be useful in biomonitoring of exposure to aquatic pollutants.

Authors+Show Affiliations

Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11503072

Citation

Pandey, S, et al. "Effect of Endosulfan On Antioxidants of Freshwater Fish Channa Punctatus Bloch: 1. Protection Against Lipid Peroxidation in Liver By Copper Preexposure." Archives of Environmental Contamination and Toxicology, vol. 41, no. 3, 2001, pp. 345-52.
Pandey S, Ahmad I, Parvez S, et al. Effect of endosulfan on antioxidants of freshwater fish Channa punctatus Bloch: 1. Protection against lipid peroxidation in liver by copper preexposure. Arch Environ Contam Toxicol. 2001;41(3):345-52.
Pandey, S., Ahmad, I., Parvez, S., Bin-Hafeez, B., Haque, R., & Raisuddin, S. (2001). Effect of endosulfan on antioxidants of freshwater fish Channa punctatus Bloch: 1. Protection against lipid peroxidation in liver by copper preexposure. Archives of Environmental Contamination and Toxicology, 41(3), 345-52.
Pandey S, et al. Effect of Endosulfan On Antioxidants of Freshwater Fish Channa Punctatus Bloch: 1. Protection Against Lipid Peroxidation in Liver By Copper Preexposure. Arch Environ Contam Toxicol. 2001;41(3):345-52. PubMed PMID: 11503072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of endosulfan on antioxidants of freshwater fish Channa punctatus Bloch: 1. Protection against lipid peroxidation in liver by copper preexposure. AU - Pandey,S, AU - Ahmad,I, AU - Parvez,S, AU - Bin-Hafeez,B, AU - Haque,R, AU - Raisuddin,S, PY - 2000/11/28/received PY - 2001/04/14/accepted PY - 2001/8/15/pubmed PY - 2001/10/5/medline PY - 2001/8/15/entrez SP - 345 EP - 52 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 41 IS - 3 N2 - Effect of a single exposure of endosulfan (5 ppb) on catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and reduced glutathione (GSH) of liver, kidney, and gill of a freshwater fish (Channa punctatus Bloch) were evaluated after 24 h of treatment. Endosulfan exposure resulted in a significant induction (p < 0.05-0.001) of GPx, GST activity, and GSH levels in all the organs. However, CAT activity was found to be significantly decreased (p < 0.01-0.001). Lipid peroxidation (LPO) values were also determined in liver, kidney, and gill and a significant increase in LPO values (p < 0.05-0.01) was observed in all the organs. We also investigated whether preexposure to low concentration of copper (10 ppb) for 4 weeks has any protective effect against endosulfan-induced oxidative damage. In copper-acclimatized endosulfan-exposed fish, a significant decrease in GPx (p < 0.001), GST (p < 0.05), GSH (p < 0.001) levels, and LPO (p < 0.01) was observed in the liver, whereas CAT activity was increased significantly (p < 0.001). However, kidney and gill did not show any significant alterations in antioxidant levels. The results of this study demonstrate that endosulfan induces peroxidative damage in liver, kidney, and gill in response to which levels of antioxidant were modulated. However, when fish preacclimatized to copper were exposed to endosulfan, protection against oxidative damage was observed only in the liver. It is proposed that measurement of antioxidants in fish tissues may prove to be useful in biomonitoring of exposure to aquatic pollutants. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/11503072/Effect_of_endosulfan_on_antioxidants_of_freshwater_fish_Channa_punctatus_Bloch:_1__Protection_against_lipid_peroxidation_in_liver_by_copper_preexposure_ L2 - https://dx.doi.org/10.1007/s002440010258 DB - PRIME DP - Unbound Medicine ER -