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Abnormal chromatographic patterns of porphyrins in urine.
Ann Clin Lab Sci. 2001 Jul; 31(3):259-64.AC

Abstract

Urine is the most frequent specimen used in the initial evaluation of adult patients who present with photosensitivity. When urine porphyrins are abnormal, characterization of the chromatogram is facilitated by calculation of uroporphyrin-to-heptacarboxylate porphyrin (uro/hepta) and uroporphyrin-to-isocoproporphyrin (uro/iso) ratios. The most frequent abnormal pattern, and that most consistent with porphyria cutanea tarda (PCT), is an uro/hepta ratio < or =2.0 and an uro/iso ratio < or =18. When the uro/hepta or uro/iso ratios are less consistent with PCT, other less common porphyrin disorders should be considered. These include variegate porphyria, coproporphyria with manifestations of photosensitivity only, adult onset congenital porphyria, mixed porphyrias, and other less frequent porphyrin disorders. After initial evaluation, the diagnosis should ideally be confirmed by additional testing of blood and fecal specimens. Most attacks of the acute porphyrias are associated with a uro/hepta ratio >4, and can be confirmed by an elevated urine porphobilinogen concentration.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Children's and Women's Health Centre of British Columbia, Vancouver, Canada. knuttall@cw.bc.ca

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11508829

Citation

Nuttall, K L.. "Abnormal Chromatographic Patterns of Porphyrins in Urine." Annals of Clinical and Laboratory Science, vol. 31, no. 3, 2001, pp. 259-64.
Nuttall KL. Abnormal chromatographic patterns of porphyrins in urine. Ann Clin Lab Sci. 2001;31(3):259-64.
Nuttall, K. L. (2001). Abnormal chromatographic patterns of porphyrins in urine. Annals of Clinical and Laboratory Science, 31(3), 259-64.
Nuttall KL. Abnormal Chromatographic Patterns of Porphyrins in Urine. Ann Clin Lab Sci. 2001;31(3):259-64. PubMed PMID: 11508829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal chromatographic patterns of porphyrins in urine. A1 - Nuttall,K L, PY - 2001/8/18/pubmed PY - 2002/1/30/medline PY - 2001/8/18/entrez SP - 259 EP - 64 JF - Annals of clinical and laboratory science JO - Ann. Clin. Lab. Sci. VL - 31 IS - 3 N2 - Urine is the most frequent specimen used in the initial evaluation of adult patients who present with photosensitivity. When urine porphyrins are abnormal, characterization of the chromatogram is facilitated by calculation of uroporphyrin-to-heptacarboxylate porphyrin (uro/hepta) and uroporphyrin-to-isocoproporphyrin (uro/iso) ratios. The most frequent abnormal pattern, and that most consistent with porphyria cutanea tarda (PCT), is an uro/hepta ratio < or =2.0 and an uro/iso ratio < or =18. When the uro/hepta or uro/iso ratios are less consistent with PCT, other less common porphyrin disorders should be considered. These include variegate porphyria, coproporphyria with manifestations of photosensitivity only, adult onset congenital porphyria, mixed porphyrias, and other less frequent porphyrin disorders. After initial evaluation, the diagnosis should ideally be confirmed by additional testing of blood and fecal specimens. Most attacks of the acute porphyrias are associated with a uro/hepta ratio >4, and can be confirmed by an elevated urine porphobilinogen concentration. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/11508829/Abnormal_chromatographic_patterns_of_porphyrins_in_urine_ L2 - http://www.annclinlabsci.org/cgi/pmidlookup?view=long&amp;pmid=11508829 DB - PRIME DP - Unbound Medicine ER -