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Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome.
Br J Nutr 2001; 85 Suppl 2:S109-13BJ

Abstract

Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet known to be deficient in vitamin B12. In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered. In this review, is described the metabolism of and interrelations between folate, vitamin B12 and homocysteine. This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome.

Authors+Show Affiliations

Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway. helga.refsum@farm.uib.no

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11509098

Citation

Refsum, H. "Folate, Vitamin B12 and Homocysteine in Relation to Birth Defects and Pregnancy Outcome." The British Journal of Nutrition, vol. 85 Suppl 2, 2001, pp. S109-13.
Refsum H. Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr. 2001;85 Suppl 2:S109-13.
Refsum, H. (2001). Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. The British Journal of Nutrition, 85 Suppl 2, pp. S109-13.
Refsum H. Folate, Vitamin B12 and Homocysteine in Relation to Birth Defects and Pregnancy Outcome. Br J Nutr. 2001;85 Suppl 2:S109-13. PubMed PMID: 11509098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. A1 - Refsum,H, PY - 2001/8/18/pubmed PY - 2001/8/31/medline PY - 2001/8/18/entrez SP - S109 EP - 13 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 85 Suppl 2 N2 - Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet known to be deficient in vitamin B12. In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered. In this review, is described the metabolism of and interrelations between folate, vitamin B12 and homocysteine. This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11509098/Folate_vitamin_B12_and_homocysteine_in_relation_to_birth_defects_and_pregnancy_outcome_ L2 - https://www.cambridge.org/core/product/identifier/S000711450100099X/type/journal_article DB - PRIME DP - Unbound Medicine ER -