Tags

Type your tag names separated by a space and hit enter

Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.
J Immunol. 2001 Sep 01; 167(5):2671-6.JI

Abstract

Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.

Authors+Show Affiliations

Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11509610

Citation

Zhu, G, et al. "Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic Mice." Journal of Immunology (Baltimore, Md. : 1950), vol. 167, no. 5, 2001, pp. 2671-6.
Zhu G, Flies DB, Tamada K, et al. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. J Immunol. 2001;167(5):2671-6.
Zhu, G., Flies, D. B., Tamada, K., Sun, Y., Rodriguez, M., Fu, Y. X., & Chen, L. (2001). Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. Journal of Immunology (Baltimore, Md. : 1950), 167(5), 2671-6.
Zhu G, et al. Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic Mice. J Immunol. 2001 Sep 1;167(5):2671-6. PubMed PMID: 11509610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. AU - Zhu,G, AU - Flies,D B, AU - Tamada,K, AU - Sun,Y, AU - Rodriguez,M, AU - Fu,Y X, AU - Chen,L, PY - 2001/8/18/pubmed PY - 2002/1/5/medline PY - 2001/8/18/entrez SP - 2671 EP - 6 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 167 IS - 5 N2 - Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/11509610/Progressive_depletion_of_peripheral_B_lymphocytes_in_4_1BB__CD137__ligand/I_Ealpha__transgenic_mice_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=11509610 DB - PRIME DP - Unbound Medicine ER -