Tags

Type your tag names separated by a space and hit enter

[Clinical significance and frequency of the 11q23/MLL genetic molecular alteration in Chilean infants with acute leukemia].
Rev Med Chil. 2001 Jun; 129(6):634-42.RM

Abstract

BACKGROUND

Acute leukemia (AL) in infants generally shows distinctive biologic features and has a poor prognosis.

AIM

To study the frequency of the cytogenetic alteration of 11q23 chromosome or the recombination of MLL gene in infants less than 18 months old, with acute leukemia.

PATIENTS AND METHODS

We analyzed 37 cases of AL in infants less than 18 months of age diagnosed in Chile from 1989 to 1999. The clinical features and cytogenetic/molecular defects of 11q23MLL gene rearrangement and their influence in prognosis were determined.

RESULTS

There were 18 cases of acute Lymphoblastic leukemia (ALL) characterized by female sex (67%) high presenting leukocyte count (median 99 x 109/L), blast cells with a CD10 negative phenotype (50%) and 11q23/MLL rearrangement (39%). Molecular abnormalities of 11q23 were significantly associated with adverse prognosis, with an event free survival (EFS) of only 14 +/- 12%. Interestingly, infants with germ line 11q23 had a very good outcome with an EFS of 73 +/- 11% (p < 0.025). There were 19 cases of acute myeloblastic leukemia (AML) characterized by male sex (63%) high leukocyte count (median 93 x 109/L), FAB-MS morphology (53%) and 11q23/MLL rearrangement (53%). EFS was very poor, 20 +/- 9% and 33 +/- 4% for rearranged and germinal group respectively (p = NS), due to a high mortality rate during the first month of diagnosis.

CONCLUSIONS

These findings demonstrate that Chilean ALL infants with 11q23 abnormalities have a very poor prognosis. However those with germinal state can enjoy a prolonged disease free survival with the current treatment protocols.

Authors+Show Affiliations

Departamento de Medicina, Campus Oriente, Facultad de Medicina Universidad de Chile. mcabrera@mi-mail.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

11510203

Citation

Cabrera, M E., et al. "[Clinical Significance and Frequency of the 11q23/MLL Genetic Molecular Alteration in Chilean Infants With Acute Leukemia]." Revista Medica De Chile, vol. 129, no. 6, 2001, pp. 634-42.
Cabrera ME, Campbell M, Quintana J, et al. [Clinical significance and frequency of the 11q23/MLL genetic molecular alteration in Chilean infants with acute leukemia]. Rev Med Chil. 2001;129(6):634-42.
Cabrera, M. E., Campbell, M., Quintana, J., Undurraga, M. S., Ford, A. A., & Greaves, M. F. (2001). [Clinical significance and frequency of the 11q23/MLL genetic molecular alteration in Chilean infants with acute leukemia]. Revista Medica De Chile, 129(6), 634-42.
Cabrera ME, et al. [Clinical Significance and Frequency of the 11q23/MLL Genetic Molecular Alteration in Chilean Infants With Acute Leukemia]. Rev Med Chil. 2001;129(6):634-42. PubMed PMID: 11510203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical significance and frequency of the 11q23/MLL genetic molecular alteration in Chilean infants with acute leukemia]. AU - Cabrera,M E, AU - Campbell,M, AU - Quintana,J, AU - Undurraga,M S, AU - Ford,A A, AU - Greaves,M F, PY - 2001/8/21/pubmed PY - 2001/10/5/medline PY - 2001/8/21/entrez SP - 634 EP - 42 JF - Revista medica de Chile JO - Rev Med Chil VL - 129 IS - 6 N2 - BACKGROUND: Acute leukemia (AL) in infants generally shows distinctive biologic features and has a poor prognosis. AIM: To study the frequency of the cytogenetic alteration of 11q23 chromosome or the recombination of MLL gene in infants less than 18 months old, with acute leukemia. PATIENTS AND METHODS: We analyzed 37 cases of AL in infants less than 18 months of age diagnosed in Chile from 1989 to 1999. The clinical features and cytogenetic/molecular defects of 11q23MLL gene rearrangement and their influence in prognosis were determined. RESULTS: There were 18 cases of acute Lymphoblastic leukemia (ALL) characterized by female sex (67%) high presenting leukocyte count (median 99 x 109/L), blast cells with a CD10 negative phenotype (50%) and 11q23/MLL rearrangement (39%). Molecular abnormalities of 11q23 were significantly associated with adverse prognosis, with an event free survival (EFS) of only 14 +/- 12%. Interestingly, infants with germ line 11q23 had a very good outcome with an EFS of 73 +/- 11% (p < 0.025). There were 19 cases of acute myeloblastic leukemia (AML) characterized by male sex (63%) high leukocyte count (median 93 x 109/L), FAB-MS morphology (53%) and 11q23/MLL rearrangement (53%). EFS was very poor, 20 +/- 9% and 33 +/- 4% for rearranged and germinal group respectively (p = NS), due to a high mortality rate during the first month of diagnosis. CONCLUSIONS: These findings demonstrate that Chilean ALL infants with 11q23 abnormalities have a very poor prognosis. However those with germinal state can enjoy a prolonged disease free survival with the current treatment protocols. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/11510203/[Clinical_significance_and_frequency_of_the_11q23/MLL_genetic_molecular_alteration_in_Chilean_infants_with_acute_leukemia]_ L2 - https://medlineplus.gov/acutemyeloidleukemia.html DB - PRIME DP - Unbound Medicine ER -