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Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure.
. 2001 Sep; 281(3):H995-1004.

Abstract

We have demonstrated a decreased neuronal nitric oxide (NO) synthase (nNOS) message in the hypothalamus of rats with heart failure (HF). Subsequently, we have demonstrated that NADPH diaphorase (a commonly used marker for nNOS activity) positive neurons are decreased in paraventricular nucleus (PVN) of rats with coronary artery ligation model of HF. The goal of the present study was to examine the influence of endogenous NO within the PVN on renal sympathetic nerve discharge (RSND) during HF. In alpha-chloralose- and urethane-anesthetized rats, an inhibitor of NO synthase, N(G)-monomethyl-L-arginine (L-NMMA) microinjected into the PVN (50, 100, and 200 pmol in 50-200 nl) produced a dose-dependent increase in RSND, blood pressure, and heart rate in control and HF rats. These responses were attenuated in rats with HF compared with control rats. On the other hand, the NO agonist, sodium nitroprusside, microinjected in PVN produced a dose-dependent decrease in RSND and blood pressure in control and HF rats. These responses were less in rats with HF compared with control rats. These data suggest that the endogenous NO-mediated effect within the PVN of HF rats is less potent in suppressing RSND compared with control rats. These data support the conclusion that the NO system within the PVN involved in controlling autonomic outflow is altered during HF and may contribute to the elevated levels of renal sympathoexcitation commonly observed in HF.

Authors+Show Affiliations

Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11514264

Citation

Zhang, K, et al. "Blunted Nitric Oxide-mediated Inhibition of Renal Nerve Discharge Within PVN of Rats With Heart Failure." American Journal of Physiology. Heart and Circulatory Physiology, vol. 281, no. 3, 2001, pp. H995-1004.
Zhang K, Li YF, Patel KP. Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. Am J Physiol Heart Circ Physiol. 2001;281(3):H995-1004.
Zhang, K., Li, Y. F., & Patel, K. P. (2001). Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. American Journal of Physiology. Heart and Circulatory Physiology, 281(3), H995-1004.
Zhang K, Li YF, Patel KP. Blunted Nitric Oxide-mediated Inhibition of Renal Nerve Discharge Within PVN of Rats With Heart Failure. Am J Physiol Heart Circ Physiol. 2001;281(3):H995-1004. PubMed PMID: 11514264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. AU - Zhang,K, AU - Li,Y F, AU - Patel,K P, PY - 2001/8/22/pubmed PY - 2001/9/21/medline PY - 2001/8/22/entrez SP - H995 EP - 1004 JF - American journal of physiology. Heart and circulatory physiology JO - Am. J. Physiol. Heart Circ. Physiol. VL - 281 IS - 3 N2 - We have demonstrated a decreased neuronal nitric oxide (NO) synthase (nNOS) message in the hypothalamus of rats with heart failure (HF). Subsequently, we have demonstrated that NADPH diaphorase (a commonly used marker for nNOS activity) positive neurons are decreased in paraventricular nucleus (PVN) of rats with coronary artery ligation model of HF. The goal of the present study was to examine the influence of endogenous NO within the PVN on renal sympathetic nerve discharge (RSND) during HF. In alpha-chloralose- and urethane-anesthetized rats, an inhibitor of NO synthase, N(G)-monomethyl-L-arginine (L-NMMA) microinjected into the PVN (50, 100, and 200 pmol in 50-200 nl) produced a dose-dependent increase in RSND, blood pressure, and heart rate in control and HF rats. These responses were attenuated in rats with HF compared with control rats. On the other hand, the NO agonist, sodium nitroprusside, microinjected in PVN produced a dose-dependent decrease in RSND and blood pressure in control and HF rats. These responses were less in rats with HF compared with control rats. These data suggest that the endogenous NO-mediated effect within the PVN of HF rats is less potent in suppressing RSND compared with control rats. These data support the conclusion that the NO system within the PVN involved in controlling autonomic outflow is altered during HF and may contribute to the elevated levels of renal sympathoexcitation commonly observed in HF. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/11514264/Blunted_nitric_oxide_mediated_inhibition_of_renal_nerve_discharge_within_PVN_of_rats_with_heart_failure_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.2001.281.3.H995?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -