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Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study.

Abstract

An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one epsilon4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-epsilon4, adjusted for age and stratified by gender, was significant only for women. No association was found between the epsilon-2 allele and AD or VD. The results support the notions that APOE-epsilon4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute for Biological Research and Cardiovascular Center, Faculty of Medicine, University of Zulia, Apdo. Postal 10.636, Maracaibo 4002-a, Venezuela.

    ,

    Source

    Neuroscience letters 307:1 2001 Jul 06 pg 5-8

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Apolipoprotein E4
    Apolipoproteins E
    DNA Mutational Analysis
    Dementia, Vascular
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Genetic Testing
    Genotype
    Humans
    Longitudinal Studies
    Male
    Risk Factors
    Sex Characteristics
    Venezuela

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11516561

    Citation

    Molero, A E., et al. "Modulation By Age and Gender of Risk for Alzheimer's Disease and Vascular Dementia Associated With the Apolipoprotein E-epsilon4 Allele in Latin Americans: Findings From the Maracaibo Aging Study." Neuroscience Letters, vol. 307, no. 1, 2001, pp. 5-8.
    Molero AE, Pino-Ramírez G, Maestre GE. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neurosci Lett. 2001;307(1):5-8.
    Molero, A. E., Pino-Ramírez, G., & Maestre, G. E. (2001). Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience Letters, 307(1), pp. 5-8.
    Molero AE, Pino-Ramírez G, Maestre GE. Modulation By Age and Gender of Risk for Alzheimer's Disease and Vascular Dementia Associated With the Apolipoprotein E-epsilon4 Allele in Latin Americans: Findings From the Maracaibo Aging Study. Neurosci Lett. 2001 Jul 6;307(1):5-8. PubMed PMID: 11516561.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. AU - Molero,A E, AU - Pino-Ramírez,G, AU - Maestre,G E, PY - 2001/8/23/pubmed PY - 2001/9/28/medline PY - 2001/8/23/entrez SP - 5 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 307 IS - 1 N2 - An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one epsilon4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-epsilon4, adjusted for age and stratified by gender, was significant only for women. No association was found between the epsilon-2 allele and AD or VD. The results support the notions that APOE-epsilon4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11516561/Modulation_by_age_and_gender_of_risk_for_Alzheimer's_disease_and_vascular_dementia_associated_with_the_apolipoprotein_E_epsilon4_allele_in_Latin_Americans:_findings_from_the_Maracaibo_Aging_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(01)01911-5 DB - PRIME DP - Unbound Medicine ER -