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Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study.
Neurosci Lett 2001; 307(1):5-8NL

Abstract

An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one epsilon4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-epsilon4, adjusted for age and stratified by gender, was significant only for women. No association was found between the epsilon-2 allele and AD or VD. The results support the notions that APOE-epsilon4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

Authors+Show Affiliations

Institute for Biological Research and Cardiovascular Center, Faculty of Medicine, University of Zulia, Apdo. Postal 10.636, Maracaibo 4002-a, Venezuela.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11516561

Citation

Molero, A E., et al. "Modulation By Age and Gender of Risk for Alzheimer's Disease and Vascular Dementia Associated With the Apolipoprotein E-epsilon4 Allele in Latin Americans: Findings From the Maracaibo Aging Study." Neuroscience Letters, vol. 307, no. 1, 2001, pp. 5-8.
Molero AE, Pino-Ramírez G, Maestre GE. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neurosci Lett. 2001;307(1):5-8.
Molero, A. E., Pino-Ramírez, G., & Maestre, G. E. (2001). Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience Letters, 307(1), pp. 5-8.
Molero AE, Pino-Ramírez G, Maestre GE. Modulation By Age and Gender of Risk for Alzheimer's Disease and Vascular Dementia Associated With the Apolipoprotein E-epsilon4 Allele in Latin Americans: Findings From the Maracaibo Aging Study. Neurosci Lett. 2001 Jul 6;307(1):5-8. PubMed PMID: 11516561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. AU - Molero,A E, AU - Pino-Ramírez,G, AU - Maestre,G E, PY - 2001/8/23/pubmed PY - 2001/9/28/medline PY - 2001/8/23/entrez SP - 5 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 307 IS - 1 N2 - An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one epsilon4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-epsilon4, adjusted for age and stratified by gender, was significant only for women. No association was found between the epsilon-2 allele and AD or VD. The results support the notions that APOE-epsilon4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11516561/Modulation_by_age_and_gender_of_risk_for_Alzheimer's_disease_and_vascular_dementia_associated_with_the_apolipoprotein_E_epsilon4_allele_in_Latin_Americans:_findings_from_the_Maracaibo_Aging_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(01)01911-5 DB - PRIME DP - Unbound Medicine ER -