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[Plasma homocysteine levels in patients with ischemic heart disease].
Orv Hetil 2001; 142(30):1611-5OH

Abstract

In the latest years it became clear that beside traditional cardiovascular risk factors the high plasma homocysteine level increases the risk of atherosclerotic diseases too. Metaanalysis of 27 papers found that 10% of population's coronary risk is attributable to homocysteine and a 5 mumol/l increase in its plasma level elevates the coronary risk by as much as 0.5 mumol/l cholesterol increase. Recent studies have shown an inverse relation between the levels of plasma homocysteine and that of folic acid, vitamin B6, vitamin B12. The latters are cofactors and substrates of the homocysteine and methionin metabolism. The plasma total cholesterol, HDL-cholesterol, triglyceride, lipoprotein(a), Apo A1, Apo B and homocysteine concentrations were examined in 39 patients suffering from coronary artery disease treated in the Cardiac Rehabilitation Department of our hospital. Twenty of them were treated by folic acid and vitamin B6 for a three week period. The mean (+/- SD) plasma homocysteine concentration was 15.60 +/- 6.14 mumol/l. In the treated subgroup the mean (+/- SD) plasma homocysteine concentration was 17.3 +/- 7.00 mumol/l, the mean (+/- SD) plasma folic acid level was 8.58 +/- 4.6 mumol/l. After the three week treatment period (folic acid and vitamin B6) the plasma homocysteine level decreased by 26.5% (p = 0.012), that of folic acid increased by 68.7% (p = 0.002). From the plasma lipids the level of total- and LDL-cholesterol decreased significantly (6.7% and 10.4%, P < 0.05), caused by the strict diet during hospital treatment. As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354).

Authors+Show Affiliations

Békés Megyei Képviselótestület Pándy Kálmán Kórháza, Gyula, II. Belgyógyászat-Kardiológia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hun

PubMed ID

11519232

Citation

Márk, L, et al. "[Plasma Homocysteine Levels in Patients With Ischemic Heart Disease]." Orvosi Hetilap, vol. 142, no. 30, 2001, pp. 1611-5.
Márk L, Erdei F, Márki-Zay J, et al. [Plasma homocysteine levels in patients with ischemic heart disease]. Orv Hetil. 2001;142(30):1611-5.
Márk, L., Erdei, F., Márki-Zay, J., Nagy, E., Kondacs, A., & Katona, A. (2001). [Plasma homocysteine levels in patients with ischemic heart disease]. Orvosi Hetilap, 142(30), pp. 1611-5.
Márk L, et al. [Plasma Homocysteine Levels in Patients With Ischemic Heart Disease]. Orv Hetil. 2001 Jul 29;142(30):1611-5. PubMed PMID: 11519232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Plasma homocysteine levels in patients with ischemic heart disease]. AU - Márk,L, AU - Erdei,F, AU - Márki-Zay,J, AU - Nagy,E, AU - Kondacs,A, AU - Katona,A, PY - 2001/8/25/pubmed PY - 2002/3/19/medline PY - 2001/8/25/entrez SP - 1611 EP - 5 JF - Orvosi hetilap JO - Orv Hetil VL - 142 IS - 30 N2 - In the latest years it became clear that beside traditional cardiovascular risk factors the high plasma homocysteine level increases the risk of atherosclerotic diseases too. Metaanalysis of 27 papers found that 10% of population's coronary risk is attributable to homocysteine and a 5 mumol/l increase in its plasma level elevates the coronary risk by as much as 0.5 mumol/l cholesterol increase. Recent studies have shown an inverse relation between the levels of plasma homocysteine and that of folic acid, vitamin B6, vitamin B12. The latters are cofactors and substrates of the homocysteine and methionin metabolism. The plasma total cholesterol, HDL-cholesterol, triglyceride, lipoprotein(a), Apo A1, Apo B and homocysteine concentrations were examined in 39 patients suffering from coronary artery disease treated in the Cardiac Rehabilitation Department of our hospital. Twenty of them were treated by folic acid and vitamin B6 for a three week period. The mean (+/- SD) plasma homocysteine concentration was 15.60 +/- 6.14 mumol/l. In the treated subgroup the mean (+/- SD) plasma homocysteine concentration was 17.3 +/- 7.00 mumol/l, the mean (+/- SD) plasma folic acid level was 8.58 +/- 4.6 mumol/l. After the three week treatment period (folic acid and vitamin B6) the plasma homocysteine level decreased by 26.5% (p = 0.012), that of folic acid increased by 68.7% (p = 0.002). From the plasma lipids the level of total- and LDL-cholesterol decreased significantly (6.7% and 10.4%, P < 0.05), caused by the strict diet during hospital treatment. As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354). SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/11519232/[Plasma_homocysteine_levels_in_patients_with_ischemic_heart_disease]_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -