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Microchip capillary electrophoresis/electrochemistry.
Electrophoresis. 2001 Aug; 22(12):2526-36.E

Abstract

Microfabricated fluidic devices have generated considerable interest over the past ten years due to the fact that sample preparation, injection, separation, derivatization, and detection can be integrated into one miniaturized device. This review reports progress in the development of microfabricated analytical systems based on microchip capillary electrophoresis (CE) with electrochemical (EC) detection. Electrochemical detection has several advantages for use with microchip electrophoresis systems, for example, ease of miniaturization, sensitivity, and selectivity. In this review, the basic components necessary for microchip CEEC are described, including several examples of different detector configurations. Lastly, details of the application of this technique to the determination of catechols and phenols, amino acids, peptides, carbohydrates, nitroaromatics, polymerase chain reaction (PCR) products, organophosphates, and hydrazines are described.

Authors+Show Affiliations

Lacher NA
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA.
Garrison KE
No affiliation info available
Martin RS
No affiliation info available
Lunte SM
No affiliation info available

MeSH

Amino AcidsCarbohydratesCarbonCatecholsElectrochemistryElectrodesElectrophoresis, CapillaryEquipment DesignGoldMicrochemistryOligonucleotide Array Sequence AnalysisPeptidesPlatinumSpecimen Handling

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11519957

Citation

Lacher, N A., et al. "Microchip Capillary Electrophoresis/electrochemistry." Electrophoresis, vol. 22, no. 12, 2001, pp. 2526-36.
Lacher NA, Garrison KE, Martin RS, et al. Microchip capillary electrophoresis/electrochemistry. Electrophoresis. 2001;22(12):2526-36.
Lacher, N. A., Garrison, K. E., Martin, R. S., & Lunte, S. M. (2001). Microchip capillary electrophoresis/electrochemistry. Electrophoresis, 22(12), 2526-36.
Lacher NA, et al. Microchip Capillary Electrophoresis/electrochemistry. Electrophoresis. 2001;22(12):2526-36. PubMed PMID: 11519957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microchip capillary electrophoresis/electrochemistry. AU - Lacher,N A, AU - Garrison,K E, AU - Martin,R S, AU - Lunte,S M, PY - 2001/8/25/pubmed PY - 2002/2/8/medline PY - 2001/8/25/entrez SP - 2526 EP - 36 JF - Electrophoresis JO - Electrophoresis VL - 22 IS - 12 N2 - Microfabricated fluidic devices have generated considerable interest over the past ten years due to the fact that sample preparation, injection, separation, derivatization, and detection can be integrated into one miniaturized device. This review reports progress in the development of microfabricated analytical systems based on microchip capillary electrophoresis (CE) with electrochemical (EC) detection. Electrochemical detection has several advantages for use with microchip electrophoresis systems, for example, ease of miniaturization, sensitivity, and selectivity. In this review, the basic components necessary for microchip CEEC are described, including several examples of different detector configurations. Lastly, details of the application of this technique to the determination of catechols and phenols, amino acids, peptides, carbohydrates, nitroaromatics, polymerase chain reaction (PCR) products, organophosphates, and hydrazines are described. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/11519957/Microchip_capillary_electrophoresis/electrochemistry_ L2 - https://doi.org/10.1002/1522-2683(200107)22:12<2526::AID-ELPS2526>3.0.CO;2-K DB - PRIME DP - Unbound Medicine ER -