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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science 2001; 293(5534):1487-91Sci

Abstract

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or Abeta influences the formation of neurofibrillary tangles. The interaction between Abeta and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease.

Authors+Show Affiliations

Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11520987

Citation

Lewis, J, et al. "Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP." Science (New York, N.Y.), vol. 293, no. 5534, 2001, pp. 1487-91.
Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001;293(5534):1487-91.
Lewis, J., Dickson, D. W., Lin, W. L., Chisholm, L., Corral, A., Jones, G., ... McGowan, E. (2001). Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (New York, N.Y.), 293(5534), pp. 1487-91.
Lewis J, et al. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP. Science. 2001 Aug 24;293(5534):1487-91. PubMed PMID: 11520987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. AU - Lewis,J, AU - Dickson,D W, AU - Lin,W L, AU - Chisholm,L, AU - Corral,A, AU - Jones,G, AU - Yen,S H, AU - Sahara,N, AU - Skipper,L, AU - Yager,D, AU - Eckman,C, AU - Hardy,J, AU - Hutton,M, AU - McGowan,E, PY - 2001/8/25/pubmed PY - 2001/9/21/medline PY - 2001/8/25/entrez SP - 1487 EP - 91 JF - Science (New York, N.Y.) JO - Science VL - 293 IS - 5534 N2 - JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or Abeta influences the formation of neurofibrillary tangles. The interaction between Abeta and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/11520987/Enhanced_neurofibrillary_degeneration_in_transgenic_mice_expressing_mutant_tau_and_APP_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11520987 DB - PRIME DP - Unbound Medicine ER -