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Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate.
Ann Oncol 2001; 12(7):953-5AO

Abstract

Mucositis is still a leading side effect of high dose chemotherapy and irradiation delivered in autologous and allogeneic bone marrow transplantation. In this double blind randomised study, we tested the efficacy of sucralfate for the prevention of mucositis induced by such conditioning treatments. Treatment was started one day before conditioning regimen and patients were prospectively evaluated. The main endpoint was severe mucositis that was more frequent in the placebo group than in the sucralfate group (47% vs. 29%, P = 0.07). This trend was confirmed after adjustment on total body irradiation (TBI) (P = 0.06), the sole stratification parameter. Interestingly, patients receiving sucralfate showed a significant reduction of diarrhoea (25%) vs. 53%, P = 0.005). Overall, the preventive administration of sucralfate appears to be an effective procedure to diminish the occurrence of severe oral and intestinal mucositis in patients treated by high dose chemotherapy alone or combined with TBI before bone marrow transplantation.

Authors+Show Affiliations

Department of Haematology, Institut Gustave Roussy, Villejuif, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11521801

Citation

Castagna, L, et al. "Prevention of Mucositis in Bone Marrow Transplantation: a Double Blind Randomised Controlled Trial of Sucralfate." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 12, no. 7, 2001, pp. 953-5.
Castagna L, Benhamou E, Pedraza E, et al. Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate. Ann Oncol. 2001;12(7):953-5.
Castagna, L., Benhamou, E., Pedraza, E., Luboinski, M., Forni, M., Brandes, I., ... Dietrich, P. Y. (2001). Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 12(7), pp. 953-5.
Castagna L, et al. Prevention of Mucositis in Bone Marrow Transplantation: a Double Blind Randomised Controlled Trial of Sucralfate. Ann Oncol. 2001;12(7):953-5. PubMed PMID: 11521801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of mucositis in bone marrow transplantation: a double blind randomised controlled trial of sucralfate. AU - Castagna,L, AU - Benhamou,E, AU - Pedraza,E, AU - Luboinski,M, AU - Forni,M, AU - Brandes,I, AU - Pico,J L, AU - Dietrich,P Y, PY - 2001/8/28/pubmed PY - 2002/2/6/medline PY - 2001/8/28/entrez SP - 953 EP - 5 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 12 IS - 7 N2 - Mucositis is still a leading side effect of high dose chemotherapy and irradiation delivered in autologous and allogeneic bone marrow transplantation. In this double blind randomised study, we tested the efficacy of sucralfate for the prevention of mucositis induced by such conditioning treatments. Treatment was started one day before conditioning regimen and patients were prospectively evaluated. The main endpoint was severe mucositis that was more frequent in the placebo group than in the sucralfate group (47% vs. 29%, P = 0.07). This trend was confirmed after adjustment on total body irradiation (TBI) (P = 0.06), the sole stratification parameter. Interestingly, patients receiving sucralfate showed a significant reduction of diarrhoea (25%) vs. 53%, P = 0.005). Overall, the preventive administration of sucralfate appears to be an effective procedure to diminish the occurrence of severe oral and intestinal mucositis in patients treated by high dose chemotherapy alone or combined with TBI before bone marrow transplantation. SN - 0923-7534 UR - https://www.unboundmedicine.com/medline/citation/11521801/Prevention_of_mucositis_in_bone_marrow_transplantation:_a_double_blind_randomised_controlled_trial_of_sucralfate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(19)54180-1 DB - PRIME DP - Unbound Medicine ER -