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Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.
Diabetes Care 2001; 24(9):1629-33DC

Abstract

OBJECTIVE

To investigate whether cardiovascular risk factors cluster with hyperinsulinemia in elderly type 2 diabetic subjects and, if so, whether this clustering predicts coronary heart disease (CHD) events during a 7-year follow-up.

RESEARCH DESIGN AND METHODS

Clustering of cardiovascular risk factors was analyzed by factor analysis. Cox regression models were used to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) during a 7-year follow-up in 229 type 2 diabetic subjects aged 65-74 years.

RESULTS

There were 70 CHD events (21 in men and 49 in women) during the follow-up period. In diabetic men, components of the insulin resistance syndrome (IRS) loaded on Factor 1 (the insulin resistance factor), which reflected high fasting insulin, obesity (high BMI), central obesity (high waist-to-hip ratio), high total triglycerides, and a short duration of diabetes. Only this IRS factor predicted CHD events in multivariate Cox regression analysis (hazard ratio [HR] 1.71, 95% CI 1.08-2.71, P = 0.022). In diabetic women, components of IRS loaded on two factors, none of which predicted CHD events. In women, only Factor 4, characterized by advanced age, left ventricular hypertrophy on electrocardiogram, high alcohol consumption, high systolic blood pressure, and albuminuria, predicted CHD events in multivariate Cox regression analysis (1.34, 1.03-1.74, P = 0.03).

CONCLUSIONS

IRS is a risk factor for CHD in elderly type 2 diabetic men.

Authors+Show Affiliations

Department of Medicine, University of Kuopio, FIN-70211 Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11522711

Citation

Kuusisto, J, et al. "Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Type 2 Diabetic Men." Diabetes Care, vol. 24, no. 9, 2001, pp. 1629-33.
Kuusisto J, Lempiäinen P, Mykkänen L, et al. Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men. Diabetes Care. 2001;24(9):1629-33.
Kuusisto, J., Lempiäinen, P., Mykkänen, L., & Laakso, M. (2001). Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men. Diabetes Care, 24(9), pp. 1629-33.
Kuusisto J, et al. Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Type 2 Diabetic Men. Diabetes Care. 2001;24(9):1629-33. PubMed PMID: 11522711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men. AU - Kuusisto,J, AU - Lempiäinen,P, AU - Mykkänen,L, AU - Laakso,M, PY - 2001/8/28/pubmed PY - 2001/10/12/medline PY - 2001/8/28/entrez SP - 1629 EP - 33 JF - Diabetes care JO - Diabetes Care VL - 24 IS - 9 N2 - OBJECTIVE: To investigate whether cardiovascular risk factors cluster with hyperinsulinemia in elderly type 2 diabetic subjects and, if so, whether this clustering predicts coronary heart disease (CHD) events during a 7-year follow-up. RESEARCH DESIGN AND METHODS: Clustering of cardiovascular risk factors was analyzed by factor analysis. Cox regression models were used to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) during a 7-year follow-up in 229 type 2 diabetic subjects aged 65-74 years. RESULTS: There were 70 CHD events (21 in men and 49 in women) during the follow-up period. In diabetic men, components of the insulin resistance syndrome (IRS) loaded on Factor 1 (the insulin resistance factor), which reflected high fasting insulin, obesity (high BMI), central obesity (high waist-to-hip ratio), high total triglycerides, and a short duration of diabetes. Only this IRS factor predicted CHD events in multivariate Cox regression analysis (hazard ratio [HR] 1.71, 95% CI 1.08-2.71, P = 0.022). In diabetic women, components of IRS loaded on two factors, none of which predicted CHD events. In women, only Factor 4, characterized by advanced age, left ventricular hypertrophy on electrocardiogram, high alcohol consumption, high systolic blood pressure, and albuminuria, predicted CHD events in multivariate Cox regression analysis (1.34, 1.03-1.74, P = 0.03). CONCLUSIONS: IRS is a risk factor for CHD in elderly type 2 diabetic men. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/11522711/Insulin_resistance_syndrome_predicts_coronary_heart_disease_events_in_elderly_type_2_diabetic_men_ DB - PRIME DP - Unbound Medicine ER -