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Real time analysis of breath volatiles using SIFT-MS in cigarette smoking.
Redox Rep. 2001; 6(3):185-7.RR

Abstract

The selected ion flow tube mass spectrometry (SIFT-MS) technique enables real time analysis of trace volatiles at ppb levels without preconcentration steps or chemical derivatization. Most previous studies of trace compounds on the breath were analyzed using gas chromatography where enhanced detection sensitivity was achieved by concentrating the breath using cryogenic or adsorption trapping techniques. In this paper, we have examined volatile organic substances, isoprene, acetone, ammonia and ethanol in breath before and after smoking a cigarette. It is interesting that isoprene levels increased in all the subjects after smoking one cigarette with a mean increase of 70%. The mean increase for acetone was found to be 22%. In contrast to isoprene, a decreasing ethanol level was observed in all the subjects except one with the negative mean decrease of 28%. Further SIFT-MS studies also have high-lighted some organic substances produced even by unburned cigarettes, US and New Zealand products. Certain US brands have shown much higher levels of volatile species than cigarettes produced in New Zealand.

Authors+Show Affiliations

Department of Chemical and Process Engineering, University of Canterbury, Christchurch, New Zealand. senti@cape.canterbury.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11523595

Citation

Senthilmohan, S T., et al. "Real Time Analysis of Breath Volatiles Using SIFT-MS in Cigarette Smoking." Redox Report : Communications in Free Radical Research, vol. 6, no. 3, 2001, pp. 185-7.
Senthilmohan ST, McEwan MJ, Wilson PF, et al. Real time analysis of breath volatiles using SIFT-MS in cigarette smoking. Redox Rep. 2001;6(3):185-7.
Senthilmohan, S. T., McEwan, M. J., Wilson, P. F., Milligan, D. B., & Freeman, C. G. (2001). Real time analysis of breath volatiles using SIFT-MS in cigarette smoking. Redox Report : Communications in Free Radical Research, 6(3), 185-7.
Senthilmohan ST, et al. Real Time Analysis of Breath Volatiles Using SIFT-MS in Cigarette Smoking. Redox Rep. 2001;6(3):185-7. PubMed PMID: 11523595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Real time analysis of breath volatiles using SIFT-MS in cigarette smoking. AU - Senthilmohan,S T, AU - McEwan,M J, AU - Wilson,P F, AU - Milligan,D B, AU - Freeman,C G, PY - 2001/8/29/pubmed PY - 2002/2/22/medline PY - 2001/8/29/entrez SP - 185 EP - 7 JF - Redox report : communications in free radical research JO - Redox Rep VL - 6 IS - 3 N2 - The selected ion flow tube mass spectrometry (SIFT-MS) technique enables real time analysis of trace volatiles at ppb levels without preconcentration steps or chemical derivatization. Most previous studies of trace compounds on the breath were analyzed using gas chromatography where enhanced detection sensitivity was achieved by concentrating the breath using cryogenic or adsorption trapping techniques. In this paper, we have examined volatile organic substances, isoprene, acetone, ammonia and ethanol in breath before and after smoking a cigarette. It is interesting that isoprene levels increased in all the subjects after smoking one cigarette with a mean increase of 70%. The mean increase for acetone was found to be 22%. In contrast to isoprene, a decreasing ethanol level was observed in all the subjects except one with the negative mean decrease of 28%. Further SIFT-MS studies also have high-lighted some organic substances produced even by unburned cigarettes, US and New Zealand products. Certain US brands have shown much higher levels of volatile species than cigarettes produced in New Zealand. SN - 1351-0002 UR - https://www.unboundmedicine.com/medline/citation/11523595/Real_time_analysis_of_breath_volatiles_using_SIFT_MS_in_cigarette_smoking_ L2 - https://www.tandfonline.com/doi/full/10.1179/135100001101536166 DB - PRIME DP - Unbound Medicine ER -