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Genotype transposer: automated genotype manipulation for linkage disequilibrium analysis.

Abstract

The purpose of this work is to provide the modern molecular geneticist with tools to perform more efficient and more accurate analysis of the genotype data they produce. By using Microsoft Excel macros written in Visual Basic, we can translate genotype data into a form readable by the versatile software 'Arlequin', read the Arlequin output, calculate statistics of linkage disequilibrium, and put the results in a format for viewing with the software 'GOLD'.

AVAILABILITY

The software is available by FTP at: ftp://xcsg.iarc.fr/cox/Genotype_Transposer/.

SUPPLEMENTARY INFORMATION

Detailed instruction and examples are available at: ftp://xcsg.iarc.fr/cox/Genotype&_Transposer/. Arlequin is available at: http://lgb.unige.ch/arlequin/. GOLD is available at: http://www.well.ox.ac.uk/asthma/GOLD/.

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  • Authors

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    Source

    Bioinformatics (Oxford, England) 17:8 2001 Aug pg 738-9

    MeSH

    Computational Biology
    Genetics, Medical
    Genotype
    Haplotypes
    Humans
    Linkage Disequilibrium
    Polymorphism, Single Nucleotide
    Software
    Software Design

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11524375