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[Changes in serum malondialdehyde-modified low-density lipoprotein in patients with acute myocardial infarction and stable angina pectoris treated by coronary angioplasty].
J Cardiol. 2001 Aug; 38(2):55-60.JC

Abstract

OBJECTIVES

Serum malondialdehyde-modified low-density lipoprotein(MDA-LDL) was measured as a marker of oxidative stress, and the changes in serum MDA-LDL compared in patients with acute myocardial infarction and stable angina pectoris treated by percutaneous transluminal coronary angioplasty (PTCA).

METHODS

Forty-one patients with acute myocardial infarction or stable angina pectoris were admitted to our hospitals between January 2000 and June 2000. Direct PTCA was performed in 17 patients(MI group) and elective PTCA in 24 patients(AP group). Coronary angiography was performed in nine control subjects(control group). Serum MDA-LDL was measured in the peripheral venous blood before and immediately after procedures in each group(normal range 20-80 U/l).

RESULTS

There were no significant differences in patient characteristics, except age, between the MI group and AP group. Serum MDA-LDL was elevated above the normal range before the procedure in both groups(MI group 104.7 +/- 52.0 U/l, AP group 99.7 +/- 42.8 U/l), and significantly decreased immediately after the procedure(MI group 61.3 +/- 25.6 U/l, AP group 62.0 +/- 29.6 U/l), but there were no significant differences between the two groups. Serum MDA-LDL was elevated before the procedure (99.3 +/- 48.9 U/l) in the control group and significantly decreased immediately after the procedure(61.7 +/- 26.2 U/l). However, these values did not differ from the values before and immediately after the procedure in the MI group and the AP group. The percentage changes in serum MDA-LDL before and immediately after the procedure were -38 +/- 16% in the MI group, -37 +/- 17% in the AP group and -36 +/- 20% in the control group, and there were no significant differences between the three groups.

CONCLUSIONS

No significant difference in the changes in serum MDA-LDL was observed between patients with acute myocardial infarction and stable angina pectoris treated by PTCA. However, anticoagulants may affect the MDA-LDL measurements directly, because similar changes in serum MDA-LDL were observed in control subjects after only coronary angiography.

Authors+Show Affiliations

Department of Internal Medicine, Saiseikai Kanazawa Hospital, Akatsuchi-machi Ni 13-6, Kanazawa, Ishikawa 920-0353.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

jpn

PubMed ID

11525110

Citation

Araki, T, et al. "[Changes in Serum Malondialdehyde-modified Low-density Lipoprotein in Patients With Acute Myocardial Infarction and Stable Angina Pectoris Treated By Coronary Angioplasty]." Journal of Cardiology, vol. 38, no. 2, 2001, pp. 55-60.
Araki T, Kanaya H, Shimizu M, et al. [Changes in serum malondialdehyde-modified low-density lipoprotein in patients with acute myocardial infarction and stable angina pectoris treated by coronary angioplasty]. J Cardiol. 2001;38(2):55-60.
Araki, T., Kanaya, H., Shimizu, M., Mabuchi, H., Kitayama, M., Kanemitsu, S., & Takekoshi, N. (2001). [Changes in serum malondialdehyde-modified low-density lipoprotein in patients with acute myocardial infarction and stable angina pectoris treated by coronary angioplasty]. Journal of Cardiology, 38(2), 55-60.
Araki T, et al. [Changes in Serum Malondialdehyde-modified Low-density Lipoprotein in Patients With Acute Myocardial Infarction and Stable Angina Pectoris Treated By Coronary Angioplasty]. J Cardiol. 2001;38(2):55-60. PubMed PMID: 11525110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes in serum malondialdehyde-modified low-density lipoprotein in patients with acute myocardial infarction and stable angina pectoris treated by coronary angioplasty]. AU - Araki,T, AU - Kanaya,H, AU - Shimizu,M, AU - Mabuchi,H, AU - Kitayama,M, AU - Kanemitsu,S, AU - Takekoshi,N, AU - ,, PY - 2001/8/30/pubmed PY - 2001/10/19/medline PY - 2001/8/30/entrez SP - 55 EP - 60 JF - Journal of cardiology JO - J Cardiol VL - 38 IS - 2 N2 - OBJECTIVES: Serum malondialdehyde-modified low-density lipoprotein(MDA-LDL) was measured as a marker of oxidative stress, and the changes in serum MDA-LDL compared in patients with acute myocardial infarction and stable angina pectoris treated by percutaneous transluminal coronary angioplasty (PTCA). METHODS: Forty-one patients with acute myocardial infarction or stable angina pectoris were admitted to our hospitals between January 2000 and June 2000. Direct PTCA was performed in 17 patients(MI group) and elective PTCA in 24 patients(AP group). Coronary angiography was performed in nine control subjects(control group). Serum MDA-LDL was measured in the peripheral venous blood before and immediately after procedures in each group(normal range 20-80 U/l). RESULTS: There were no significant differences in patient characteristics, except age, between the MI group and AP group. Serum MDA-LDL was elevated above the normal range before the procedure in both groups(MI group 104.7 +/- 52.0 U/l, AP group 99.7 +/- 42.8 U/l), and significantly decreased immediately after the procedure(MI group 61.3 +/- 25.6 U/l, AP group 62.0 +/- 29.6 U/l), but there were no significant differences between the two groups. Serum MDA-LDL was elevated before the procedure (99.3 +/- 48.9 U/l) in the control group and significantly decreased immediately after the procedure(61.7 +/- 26.2 U/l). However, these values did not differ from the values before and immediately after the procedure in the MI group and the AP group. The percentage changes in serum MDA-LDL before and immediately after the procedure were -38 +/- 16% in the MI group, -37 +/- 17% in the AP group and -36 +/- 20% in the control group, and there were no significant differences between the three groups. CONCLUSIONS: No significant difference in the changes in serum MDA-LDL was observed between patients with acute myocardial infarction and stable angina pectoris treated by PTCA. However, anticoagulants may affect the MDA-LDL measurements directly, because similar changes in serum MDA-LDL were observed in control subjects after only coronary angiography. SN - 0914-5087 UR - https://www.unboundmedicine.com/medline/citation/11525110/[Changes_in_serum_malondialdehyde_modified_low_density_lipoprotein_in_patients_with_acute_myocardial_infarction_and_stable_angina_pectoris_treated_by_coronary_angioplasty]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -