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Low dietary zinc alters indices of copper function and status in postmenopausal women.

Abstract

OBJECTIVES

To better define the relationship between dietary zinc and copper for humans so that sound recommendations for intakes of these elements can be made.

METHODS

A study was conducted to ascertain the effect of moderately excessive and deficient intakes of zinc on copper metabolism and use in humans fed low and luxuriant amounts of copper. Twenty-one postmenopausal women housed in a metabolic unit completed the study as designed. After a 10-d equilibration period in which they were fed a diet providing 31.5 micromol (2 mg) Cu and 91.8 micromol (9 mg) Zn/8.4 MJ (2000 kcal), the women were divided into two groups. One group was fed a diet containing 15.7 micromol (1 mg) Cu/8.4 MJ (2000 kcal), and the other group was fed a diet containing 47.2 micromol (3 mg) Cu/8.4 MJ (2000 kcal). After equilibration, both groups were fed the basal diet providing 45.9 micromol (3 mg) Zn/8.4 MJ (2000 kcal) for 90 d; this was followed by another 10-d equilibration period before dietary zinc was increased to 811 micromol (53 mg)/8.4 MJ (2000 kcal) for 90 d.

RESULTS

The women were in positive copper balance only when the diet provided 47.2 micromol (3 mg) Cu and 811 micromol (53 mg) Zn/d. Immunoreactive ceruloplasmin concentrations and platelet cytochrome-c oxidase activity on a platelet number basis were significantly lower and the ratio between enzymatic and immunoreactive ceruloplasmin was significantly higher during low dietary than during high dietary zinc intake. Serum cholesterol was higher in subjects fed 15.7 micromol (1 mg) Cu/d than in those fed 47.2 micromol (3 mg) Cu/d. Total and low-density lipoprotein cholesterol concentrations decreased with zinc supplementation. Whole-blood glutathione concentration and erythrocyte glutathione peroxidase activity were lower during high than during low dietary zinc intake.

CONCLUSIONS

The findings indicate that an inadequate intake of zinc (45.9 micromol/d; 3 mg/d) was more effective than a moderately high intake of zinc (811 micromol/d; 53 mg/d) in inducing changes associated with a decreased copper status in postmenopausal women. Furthermore, the findings indicate that copper status indicators might be useful in evaluating changes in zinc status in humans, and an intake of 15.7 micromol (1 mg)/d of copper may be inadequate for postmenopausal women.

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  • Authors+Show Affiliations

    ,

    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202-9034, USA.

    ,

    Source

    MeSH

    Aged
    Blood Platelets
    Ceruloplasmin
    Cholesterol, HDL
    Cholesterol, LDL
    Copper
    Diet
    Electron Transport Complex IV
    Erythrocytes
    Factor VIII
    Feces
    Female
    Humans
    Middle Aged
    Nutrition Policy
    Nutritional Status
    Postmenopause
    Superoxide Dismutase
    Zinc

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11527655

    Citation

    Milne, D B., et al. "Low Dietary Zinc Alters Indices of Copper Function and Status in Postmenopausal Women." Nutrition (Burbank, Los Angeles County, Calif.), vol. 17, no. 9, 2001, pp. 701-8.
    Milne DB, Davis CD, Nielsen FH. Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition. 2001;17(9):701-8.
    Milne, D. B., Davis, C. D., & Nielsen, F. H. (2001). Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition (Burbank, Los Angeles County, Calif.), 17(9), pp. 701-8.
    Milne DB, Davis CD, Nielsen FH. Low Dietary Zinc Alters Indices of Copper Function and Status in Postmenopausal Women. Nutrition. 2001;17(9):701-8. PubMed PMID: 11527655.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low dietary zinc alters indices of copper function and status in postmenopausal women. AU - Milne,D B, AU - Davis,C D, AU - Nielsen,F H, PY - 2001/8/31/pubmed PY - 2002/1/26/medline PY - 2001/8/31/entrez SP - 701 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 17 IS - 9 N2 - OBJECTIVES: To better define the relationship between dietary zinc and copper for humans so that sound recommendations for intakes of these elements can be made. METHODS: A study was conducted to ascertain the effect of moderately excessive and deficient intakes of zinc on copper metabolism and use in humans fed low and luxuriant amounts of copper. Twenty-one postmenopausal women housed in a metabolic unit completed the study as designed. After a 10-d equilibration period in which they were fed a diet providing 31.5 micromol (2 mg) Cu and 91.8 micromol (9 mg) Zn/8.4 MJ (2000 kcal), the women were divided into two groups. One group was fed a diet containing 15.7 micromol (1 mg) Cu/8.4 MJ (2000 kcal), and the other group was fed a diet containing 47.2 micromol (3 mg) Cu/8.4 MJ (2000 kcal). After equilibration, both groups were fed the basal diet providing 45.9 micromol (3 mg) Zn/8.4 MJ (2000 kcal) for 90 d; this was followed by another 10-d equilibration period before dietary zinc was increased to 811 micromol (53 mg)/8.4 MJ (2000 kcal) for 90 d. RESULTS: The women were in positive copper balance only when the diet provided 47.2 micromol (3 mg) Cu and 811 micromol (53 mg) Zn/d. Immunoreactive ceruloplasmin concentrations and platelet cytochrome-c oxidase activity on a platelet number basis were significantly lower and the ratio between enzymatic and immunoreactive ceruloplasmin was significantly higher during low dietary than during high dietary zinc intake. Serum cholesterol was higher in subjects fed 15.7 micromol (1 mg) Cu/d than in those fed 47.2 micromol (3 mg) Cu/d. Total and low-density lipoprotein cholesterol concentrations decreased with zinc supplementation. Whole-blood glutathione concentration and erythrocyte glutathione peroxidase activity were lower during high than during low dietary zinc intake. CONCLUSIONS: The findings indicate that an inadequate intake of zinc (45.9 micromol/d; 3 mg/d) was more effective than a moderately high intake of zinc (811 micromol/d; 53 mg/d) in inducing changes associated with a decreased copper status in postmenopausal women. Furthermore, the findings indicate that copper status indicators might be useful in evaluating changes in zinc status in humans, and an intake of 15.7 micromol (1 mg)/d of copper may be inadequate for postmenopausal women. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/11527655/Low_dietary_zinc_alters_indices_of_copper_function_and_status_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(01)00560-3 DB - PRIME DP - Unbound Medicine ER -