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Diagnosis of Strongyloides stercoralis infection.
Clin Infect Dis. 2001 Oct 01; 33(7):1040-7.CI

Abstract

Strongyloides stercoralis infects 30 million people in 70 countries. Infection usually results in asymptomatic chronic disease of the gut, which can remain undetected for decades. However, in patients receiving long-term corticosteroid therapy, hyperinfection can occur, resulting in high mortality rates (up to 87%). Strongyloidiasis is difficult to diagnose because the parasite load is low and the larval output is irregular. Results of a single stool examination by use of conventional techniques fail to detect larvae in up to 70% of cases. Several immunodiagnostic assays have been found ineffective in detecting disseminated infections and show extensive cross-reactivity with hookworms, filariae, and schistosomes. Although it is important to detect latent S. stercoralis infections before administering chemotherapy or before the onset of immunosuppression in patients at risk, a specific and sensitive diagnostic test is lacking. This review describes the clinical manifestations of strongyloidiasis, as well as various diagnostic tests and treatment strategies.

Authors+Show Affiliations

Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. siddiqui@cortex.ama.ttuhsc.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11528578

Citation

Siddiqui, A A., and S L. Berk. "Diagnosis of Strongyloides Stercoralis Infection." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 33, no. 7, 2001, pp. 1040-7.
Siddiqui AA, Berk SL. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis. 2001;33(7):1040-7.
Siddiqui, A. A., & Berk, S. L. (2001). Diagnosis of Strongyloides stercoralis infection. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 33(7), 1040-7.
Siddiqui AA, Berk SL. Diagnosis of Strongyloides Stercoralis Infection. Clin Infect Dis. 2001 Oct 1;33(7):1040-7. PubMed PMID: 11528578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of Strongyloides stercoralis infection. AU - Siddiqui,A A, AU - Berk,S L, Y1 - 2001/09/05/ PY - 2001/03/09/received PY - 2001/04/25/revised PY - 2001/8/31/pubmed PY - 2002/1/5/medline PY - 2001/8/31/entrez SP - 1040 EP - 7 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 33 IS - 7 N2 - Strongyloides stercoralis infects 30 million people in 70 countries. Infection usually results in asymptomatic chronic disease of the gut, which can remain undetected for decades. However, in patients receiving long-term corticosteroid therapy, hyperinfection can occur, resulting in high mortality rates (up to 87%). Strongyloidiasis is difficult to diagnose because the parasite load is low and the larval output is irregular. Results of a single stool examination by use of conventional techniques fail to detect larvae in up to 70% of cases. Several immunodiagnostic assays have been found ineffective in detecting disseminated infections and show extensive cross-reactivity with hookworms, filariae, and schistosomes. Although it is important to detect latent S. stercoralis infections before administering chemotherapy or before the onset of immunosuppression in patients at risk, a specific and sensitive diagnostic test is lacking. This review describes the clinical manifestations of strongyloidiasis, as well as various diagnostic tests and treatment strategies. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/11528578/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/322707 DB - PRIME DP - Unbound Medicine ER -