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Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9.
Arch Surg 2001; 136(9):1014-8AS

Abstract

HYPOTHESIS

Obesity impairs the antireflux function of a structurally intact barrier.

DESIGN

Retrospective analysis of body mass index in patients with normal esophageal manometric findings but with symptomatic and objectively confirmed gastroesophageal reflux.

SETTING

Specialist esophageal center.

PATIENTS

Patients symptomatic and diagnostic for gastroesophageal reflux, referred between October 1, 1998, and June 30, 2000. Exclusion criteria were a defective barrier, motility disorders, or previous surgery.

MAIN OUTCOME MEASURES

Reflux was defined and quantified using the DeMeester score, and body mass index was calculated.

RESULTS

There was a strong correlation between body mass index and severity of gastroesophageal reflux. Patients who were overweight had significantly higher distal esophageal acid exposure. No significant difference in manometric findings was demonstrated between patients with normal weight and those who were overweight.

CONCLUSION

The barrier to gastroesophageal reflux is rendered insufficient in patients who are overweight.

Authors+Show Affiliations

Department of Surgery, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA 90033, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11529823

Citation

Wajed, S A., et al. "Elevated Body Mass Disrupts the Barrier to Gastroesophageal Reflux; Discussion 1018-9." Archives of Surgery (Chicago, Ill. : 1960), vol. 136, no. 9, 2001, pp. 1014-8.
Wajed SA, Streets CG, Bremner CG, et al. Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9. Arch Surg. 2001;136(9):1014-8.
Wajed, S. A., Streets, C. G., Bremner, C. G., & DeMeester, T. R. (2001). Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9. Archives of Surgery (Chicago, Ill. : 1960), 136(9), pp. 1014-8.
Wajed SA, et al. Elevated Body Mass Disrupts the Barrier to Gastroesophageal Reflux; Discussion 1018-9. Arch Surg. 2001;136(9):1014-8. PubMed PMID: 11529823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9. AU - Wajed,S A, AU - Streets,C G, AU - Bremner,C G, AU - DeMeester,T R, PY - 2001/9/28/pubmed PY - 2001/9/28/medline PY - 2001/9/28/entrez SP - 1014 EP - 8 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 136 IS - 9 N2 - HYPOTHESIS: Obesity impairs the antireflux function of a structurally intact barrier. DESIGN: Retrospective analysis of body mass index in patients with normal esophageal manometric findings but with symptomatic and objectively confirmed gastroesophageal reflux. SETTING: Specialist esophageal center. PATIENTS: Patients symptomatic and diagnostic for gastroesophageal reflux, referred between October 1, 1998, and June 30, 2000. Exclusion criteria were a defective barrier, motility disorders, or previous surgery. MAIN OUTCOME MEASURES: Reflux was defined and quantified using the DeMeester score, and body mass index was calculated. RESULTS: There was a strong correlation between body mass index and severity of gastroesophageal reflux. Patients who were overweight had significantly higher distal esophageal acid exposure. No significant difference in manometric findings was demonstrated between patients with normal weight and those who were overweight. CONCLUSION: The barrier to gastroesophageal reflux is rendered insufficient in patients who are overweight. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/11529823/Elevated_body_mass_disrupts_the_barrier_to_gastroesophageal_reflux L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/vol/136/pg/1014 DB - PRIME DP - Unbound Medicine ER -