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Evidence for a relationship between place-cell spatial firing and spatial memory performance.
Hippocampus. 2001; 11(4):377-90.H

Abstract

The rat hippocampus contains place cells whose firing is location-specific. Although many properties of place cells have been uncovered, little is known about their actual contribution to the animal's spatial performance. In this study, we addressed this issue by recording place cells while rats solved a continuous spatial alternation task in which they had to alternate between the two arms of a Y-maze to get a food reward in the third (goal) arm. By manipulating the information available to the animals, we induced the cells to establish their fields in locations that were out of register relative to their standard position, thus making them inconsistent with the learned spatial task. When this happened, the rats' performance in the alternation task was markedly decreased. In addition, the nature of the behavioral errors during inconsistent field placements also changed dramatically in a way that was highly indicative of the rats' spatial disorientation. These results suggest that there is a functional relationship between the spatial firing patterns of place cells and the spatial behavior of the rat, thus strengthening the idea that these cells are part of a navigational system.

Authors+Show Affiliations

Center for Research in Cognitive Neuroscience, Centre National de la Recherche Scientifique, Marseille, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11530842

Citation

Lenck-Santini, P P., et al. "Evidence for a Relationship Between Place-cell Spatial Firing and Spatial Memory Performance." Hippocampus, vol. 11, no. 4, 2001, pp. 377-90.
Lenck-Santini PP, Save E, Poucet B. Evidence for a relationship between place-cell spatial firing and spatial memory performance. Hippocampus. 2001;11(4):377-90.
Lenck-Santini, P. P., Save, E., & Poucet, B. (2001). Evidence for a relationship between place-cell spatial firing and spatial memory performance. Hippocampus, 11(4), 377-90.
Lenck-Santini PP, Save E, Poucet B. Evidence for a Relationship Between Place-cell Spatial Firing and Spatial Memory Performance. Hippocampus. 2001;11(4):377-90. PubMed PMID: 11530842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for a relationship between place-cell spatial firing and spatial memory performance. AU - Lenck-Santini,P P, AU - Save,E, AU - Poucet,B, PY - 2001/9/4/pubmed PY - 2002/1/24/medline PY - 2001/9/4/entrez SP - 377 EP - 90 JF - Hippocampus JO - Hippocampus VL - 11 IS - 4 N2 - The rat hippocampus contains place cells whose firing is location-specific. Although many properties of place cells have been uncovered, little is known about their actual contribution to the animal's spatial performance. In this study, we addressed this issue by recording place cells while rats solved a continuous spatial alternation task in which they had to alternate between the two arms of a Y-maze to get a food reward in the third (goal) arm. By manipulating the information available to the animals, we induced the cells to establish their fields in locations that were out of register relative to their standard position, thus making them inconsistent with the learned spatial task. When this happened, the rats' performance in the alternation task was markedly decreased. In addition, the nature of the behavioral errors during inconsistent field placements also changed dramatically in a way that was highly indicative of the rats' spatial disorientation. These results suggest that there is a functional relationship between the spatial firing patterns of place cells and the spatial behavior of the rat, thus strengthening the idea that these cells are part of a navigational system. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/11530842/Evidence_for_a_relationship_between_place_cell_spatial_firing_and_spatial_memory_performance_ L2 - https://doi.org/10.1002/hipo.1052 DB - PRIME DP - Unbound Medicine ER -