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Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome?
Lupus. 2001; 10(8):547-53.L

Abstract

Antibodies binding components of the Ro/La (or SSA/SSB) ribonucleoprotein particle are found in the sera of patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) as well as mothers who give birth to babies with neonatal lupus. Anti-La occurs in a subset of sera that contain anti-Ro, and anti-La is found more commonly in sera of patients with SS than in sera from SLE patients. The fine specificity of autoantibodies binding 60 kDa has been studied extensively. Recent data have suggested that there are disease-specific epitopes which identify patients with either SLE or SS. Alternatively, other data suggest that the B cell epitopes of 60kDa Ro vary according to the presence of anti-La. The present study was undertaken to determine whether binding of putative disease-specific 60 kDa Ro epitopes is associated with the diagnosis of SLE vs SS, or instead associated with the presence of anti-La. Anti-60 kDa Ro positive sera from 24 SLE patients and 44 SS patients were studied for antibodies binding two epitopes of 60 kDa Ro. We find the epitope defined by residues 171-190 is associated with anti-60 kDa Ro without anti-La, regardless of diagnosis. Meanwhile, binding of the epitope defined by residues 215-232 is not commonly found in anti-60 kDa Ro sera, especially in those sera with both anti-60 kDa Ro and anti-La. Thus, the fine specificity of antibody binding to 60 kDa Ro varies according to the presence of anti-La, not to the diagnosis of either SLE or SS.

Authors+Show Affiliations

Oklahoma Medical Research Program, University of Oklahoma Health Sciences Center, USA. hal-scofield@omrf.ouhsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11530996

Citation

Scofield, A N., et al. "Can B Cell Epitopes of 60 kDa Ro Distinguish Systemic Lupus Erythematosus From Sjögren's Syndrome?" Lupus, vol. 10, no. 8, 2001, pp. 547-53.
Scofield AN, Kurien BT, Gordon TP, et al. Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome? Lupus. 2001;10(8):547-53.
Scofield, A. N., Kurien, B. T., Gordon, T. P., & Scofield, R. H. (2001). Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome? Lupus, 10(8), 547-53.
Scofield AN, et al. Can B Cell Epitopes of 60 kDa Ro Distinguish Systemic Lupus Erythematosus From Sjögren's Syndrome. Lupus. 2001;10(8):547-53. PubMed PMID: 11530996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome? AU - Scofield,A N, AU - Kurien,B T, AU - Gordon,T P, AU - Scofield,R H, PY - 2001/9/4/pubmed PY - 2002/2/7/medline PY - 2001/9/4/entrez SP - 547 EP - 53 JF - Lupus JO - Lupus VL - 10 IS - 8 N2 - Antibodies binding components of the Ro/La (or SSA/SSB) ribonucleoprotein particle are found in the sera of patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) as well as mothers who give birth to babies with neonatal lupus. Anti-La occurs in a subset of sera that contain anti-Ro, and anti-La is found more commonly in sera of patients with SS than in sera from SLE patients. The fine specificity of autoantibodies binding 60 kDa has been studied extensively. Recent data have suggested that there are disease-specific epitopes which identify patients with either SLE or SS. Alternatively, other data suggest that the B cell epitopes of 60kDa Ro vary according to the presence of anti-La. The present study was undertaken to determine whether binding of putative disease-specific 60 kDa Ro epitopes is associated with the diagnosis of SLE vs SS, or instead associated with the presence of anti-La. Anti-60 kDa Ro positive sera from 24 SLE patients and 44 SS patients were studied for antibodies binding two epitopes of 60 kDa Ro. We find the epitope defined by residues 171-190 is associated with anti-60 kDa Ro without anti-La, regardless of diagnosis. Meanwhile, binding of the epitope defined by residues 215-232 is not commonly found in anti-60 kDa Ro sera, especially in those sera with both anti-60 kDa Ro and anti-La. Thus, the fine specificity of antibody binding to 60 kDa Ro varies according to the presence of anti-La, not to the diagnosis of either SLE or SS. SN - 0961-2033 UR - https://www.unboundmedicine.com/medline/citation/11530996/Can_B_cell_epitopes_of_60_kDa_Ro_distinguish_systemic_lupus_erythematosus_from_Sjögren's_syndrome L2 - http://journals.sagepub.com/doi/full/10.1191/096120301701549679?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -