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Glutamine alimentation in catabolic state.

Abstract

Glutamine should be reclassified as a conditionally essential amino acid in the catabolic state because the body's glutamine expenditures exceed synthesis and low glutamine levels in plasma are associated with poor clinical outcome. After severe stress, several amino acids are mobilized from muscle tissue to supply energy and substrate to the host. Glutamine is one of the most important amino acids that provide this function. Glutamine acts as the preferred respiratory fuel for lymphocytes, hepatocytes and intestinal mucosal cells and is metabolized in the gut to citrulline, ammonium and other amino acids. Low concentrations of glutamine in plasma reflect reduced stores in muscle and this reduced availability of glutamine in the catabolic state seems to correlate with increased morbidity and mortality. Adding glutamine to the nutrition of clinical patients, enterally or parenterally, may reduce morbidity. Several excellent clinical trials have been performed to prove efficacy and feasibility of the use of glutamine supplementation in parenteral and enteral nutrition. The increased intake of glutamine has resulted in lower septic morbidity in certain critically ill patient populations. This review will focus on the efficacy and the importance of glutamine supplementation in diverse catabolic states.

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  • Authors+Show Affiliations

    ,

    Department of Surgery, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.

    , , ,

    Source

    The Journal of nutrition 131:9 Suppl 2001 09 pg 2569S-77S; discussion 2590S

    MeSH

    Acquired Immunodeficiency Syndrome
    Controlled Clinical Trials as Topic
    Critical Care
    Dietary Supplements
    Elective Surgical Procedures
    Enteral Nutrition
    Glutamine
    Humans
    Nutritional Status
    Parenteral Nutrition, Total
    Stress, Physiological
    Wounds and Injuries

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    11533315

    Citation

    Boelens, P G., et al. "Glutamine Alimentation in Catabolic State." The Journal of Nutrition, vol. 131, no. 9 Suppl, 2001, 2569S-77S; discussion 2590S.
    Boelens PG, Nijveldt RJ, Houdijk AP, et al. Glutamine alimentation in catabolic state. J Nutr. 2001;131(9 Suppl):2569S-77S; discussion 2590S.
    Boelens, P. G., Nijveldt, R. J., Houdijk, A. P., Meijer, S., & van Leeuwen, P. A. (2001). Glutamine alimentation in catabolic state. The Journal of Nutrition, 131(9 Suppl), 2569S-77S; discussion 2590S. doi:10.1093/jn/131.9.2569S.
    Boelens PG, et al. Glutamine Alimentation in Catabolic State. J Nutr. 2001;131(9 Suppl):2569S-77S; discussion 2590S. PubMed PMID: 11533315.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Glutamine alimentation in catabolic state. AU - Boelens,P G, AU - Nijveldt,R J, AU - Houdijk,A P, AU - Meijer,S, AU - van Leeuwen,P A, PY - 2001/9/5/pubmed PY - 2001/10/5/medline PY - 2001/9/5/entrez SP - 2569S-77S; discussion 2590S JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 9 Suppl N2 - Glutamine should be reclassified as a conditionally essential amino acid in the catabolic state because the body's glutamine expenditures exceed synthesis and low glutamine levels in plasma are associated with poor clinical outcome. After severe stress, several amino acids are mobilized from muscle tissue to supply energy and substrate to the host. Glutamine is one of the most important amino acids that provide this function. Glutamine acts as the preferred respiratory fuel for lymphocytes, hepatocytes and intestinal mucosal cells and is metabolized in the gut to citrulline, ammonium and other amino acids. Low concentrations of glutamine in plasma reflect reduced stores in muscle and this reduced availability of glutamine in the catabolic state seems to correlate with increased morbidity and mortality. Adding glutamine to the nutrition of clinical patients, enterally or parenterally, may reduce morbidity. Several excellent clinical trials have been performed to prove efficacy and feasibility of the use of glutamine supplementation in parenteral and enteral nutrition. The increased intake of glutamine has resulted in lower septic morbidity in certain critically ill patient populations. This review will focus on the efficacy and the importance of glutamine supplementation in diverse catabolic states. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11533315/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.9.2569S DB - PRIME DP - Unbound Medicine ER -