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Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.
Pediatrics. 2001 Sep; 108(3):E50.Ped

Abstract

OBJECTIVES

To examine the genotype:phenotype association in children compared with their parents.

METHODS

Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998.

RESULTS

The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction.

CONCLUSIONS

All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics.

Authors+Show Affiliations

Center for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, London, United Kingdom. p.talmud@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11533368

Citation

Talmud, P J., et al. "Age-related Effects of Genetic Variation On Lipid Levels: the Columbia University BioMarkers Study." Pediatrics, vol. 108, no. 3, 2001, pp. E50.
Talmud PJ, Berglund L, Hawe EM, et al. Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics. 2001;108(3):E50.
Talmud, P. J., Berglund, L., Hawe, E. M., Waterworth, D. M., Isasi, C. R., Deckelbaum, R. E., Starc, T., Ginsberg, H. N., Humphries, S. E., & Shea, S. (2001). Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics, 108(3), E50.
Talmud PJ, et al. Age-related Effects of Genetic Variation On Lipid Levels: the Columbia University BioMarkers Study. Pediatrics. 2001;108(3):E50. PubMed PMID: 11533368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. AU - Talmud,P J, AU - Berglund,L, AU - Hawe,E M, AU - Waterworth,D M, AU - Isasi,C R, AU - Deckelbaum,R E, AU - Starc,T, AU - Ginsberg,H N, AU - Humphries,S E, AU - Shea,S, PY - 2001/9/5/pubmed PY - 2001/10/19/medline PY - 2001/9/5/entrez SP - E50 EP - E50 JF - Pediatrics JO - Pediatrics VL - 108 IS - 3 N2 - OBJECTIVES: To examine the genotype:phenotype association in children compared with their parents. METHODS: Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998. RESULTS: The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction. CONCLUSIONS: All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/11533368/Age_related_effects_of_genetic_variation_on_lipid_levels:_The_Columbia_University_BioMarkers_Study_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=11533368 DB - PRIME DP - Unbound Medicine ER -