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[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].
Praxis (Bern 1994). 2001 Aug 16; 90(33):1346-9.P

Abstract

Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff.

Authors+Show Affiliations

Wigger-Alberti W
Klinik für Dermatologie und dermatologische Allergologie, Friedrich-Schiller-Universität, Jena.
Kluge K
No affiliation info available
Elsner P
No affiliation info available

MeSH

AdultDermatitis, SeborrheicDermatomycosesDose-Response Relationship, DrugFemaleHair PreparationsHumansImidazolesMalasseziaMaleMiddle AgedTreatment Outcome

Pub Type(s)

Journal Article

Language

ger

PubMed ID

11534318

Citation

Wigger-Alberti, W, et al. "[Clinical Effectiveness and Tolerance of Climbazole Containing Dandruff Shampoo in Patients With Seborrheic Scalp Eczema]." Praxis, vol. 90, no. 33, 2001, pp. 1346-9.
Wigger-Alberti W, Kluge K, Elsner P. [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. Praxis (Bern 1994). 2001;90(33):1346-9.
Wigger-Alberti, W., Kluge, K., & Elsner, P. (2001). [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. Praxis, 90(33), 1346-9.
Wigger-Alberti W, Kluge K, Elsner P. [Clinical Effectiveness and Tolerance of Climbazole Containing Dandruff Shampoo in Patients With Seborrheic Scalp Eczema]. Praxis (Bern 1994). 2001 Aug 16;90(33):1346-9. PubMed PMID: 11534318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. AU - Wigger-Alberti,W, AU - Kluge,K, AU - Elsner,P, PY - 2001/9/6/pubmed PY - 2002/1/10/medline PY - 2001/9/6/entrez SP - 1346 EP - 9 JF - Praxis JO - Praxis (Bern 1994) VL - 90 IS - 33 N2 - Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff. SN - 1661-8157 UR - https://www.unboundmedicine.com/medline/citation/11534318/[Clinical_effectiveness_and_tolerance_of_climbazole_containing_dandruff_shampoo_in_patients_with_seborrheic_scalp_eczema]_ L2 - https://www.diseaseinfosearch.org/result/9652 DB - PRIME DP - Unbound Medicine ER -