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Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry.
Pharmazie. 2001 Aug; 56(8):629-32.P

Abstract

The electrochemical oxidation of olsalazine sodium was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy carbon disc electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 x 10(-6) M and 2 x 10(-4) M. This relationship has been applied to the determination of olsalazine in commercial capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.

Authors+Show Affiliations

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11534339

Citation

Uslu, B, et al. "Determination of Olsalazine Sodium in Pharmaceuticals By Differential Pulse Voltammetry." Die Pharmazie, vol. 56, no. 8, 2001, pp. 629-32.
Uslu B, Yilmaz S, Ozkan SA. Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry. Pharmazie. 2001;56(8):629-32.
Uslu, B., Yilmaz, S., & Ozkan, S. A. (2001). Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry. Die Pharmazie, 56(8), 629-32.
Uslu B, Yilmaz S, Ozkan SA. Determination of Olsalazine Sodium in Pharmaceuticals By Differential Pulse Voltammetry. Pharmazie. 2001;56(8):629-32. PubMed PMID: 11534339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry. AU - Uslu,B, AU - Yilmaz,S, AU - Ozkan,S A, PY - 2001/9/6/pubmed PY - 2001/10/5/medline PY - 2001/9/6/entrez SP - 629 EP - 32 JF - Die Pharmazie JO - Pharmazie VL - 56 IS - 8 N2 - The electrochemical oxidation of olsalazine sodium was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy carbon disc electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 x 10(-6) M and 2 x 10(-4) M. This relationship has been applied to the determination of olsalazine in commercial capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/11534339/Determination_of_olsalazine_sodium_in_pharmaceuticals_by_differential_pulse_voltammetry_ DB - PRIME DP - Unbound Medicine ER -