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[Comparative study of the eradication of Helicobacter pylori: ranitidine bismuth citrate versus omeprazole plus two antibiotics for seven days].
An Med Interna 2001; 18(7):361-3AM

Abstract

AIMS

To compare the efficacy of ranitidine bismuth citrate (RB) combined with two antibiotics during seven days in comparison with OCA-7 for treatment of Helicobacter pylori.

METHODS

In a randomized clinical trial 200, consecutive patients infected by Helicobacter pylori were studied prospectively. One of two regimens was given for 7 days; OCA-7 (omeprazole 20 mg b.i.d., amoxycillin 1 gr b.i.d., clarithromycin 500 mg b.i.d.) or RBCA (RB 400 b.i.d., amoxicillin 1 gr b.i.d., clarithromycin 500 mg b.i.d.). Eradication was defined as a negative breath test one month after therapy.

RESULTS

112 male and 88 female with a mean age of 48 years (range 18-82). 100 patients were randomized to OCA-7 and 100 patients to RBCA-7. Overall 186 patients completed the treatment. Intention to-treat eradication was in the group OCA-7 of 72% and 73% in group RBCA-7. Per-protocol eradication was in the group OCA-7 of 78% and 77% in group RBCA-7 (p = 0.3). Five patients in the group OCA-7 and nine in the group RBCA-7, had side effects, three of these patients did not complete therapy by diarrhea.

CONCLUSIONS

RB with two antibiotics is as effective and safe as OCA-7 for the eradication of Helicobacter pylori.

Authors+Show Affiliations

Servicio de Digestivo, Hospital San Eloy, Baracaldo, Vizcaya.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

spa

PubMed ID

11534420

Citation

Bujanda, L, et al. "[Comparative Study of the Eradication of Helicobacter Pylori: Ranitidine Bismuth Citrate Versus Omeprazole Plus Two Antibiotics for Seven Days]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 18, no. 7, 2001, pp. 361-3.
Bujanda L, Sánchez A, Iriondo C, et al. [Comparative study of the eradication of Helicobacter pylori: ranitidine bismuth citrate versus omeprazole plus two antibiotics for seven days]. An Med Interna. 2001;18(7):361-3.
Bujanda, L., Sánchez, A., Iriondo, C., Santos, A., Cosme, A., & Muñoz, C. (2001). [Comparative study of the eradication of Helicobacter pylori: ranitidine bismuth citrate versus omeprazole plus two antibiotics for seven days]. Anales De Medicina Interna (Madrid, Spain : 1984), 18(7), pp. 361-3.
Bujanda L, et al. [Comparative Study of the Eradication of Helicobacter Pylori: Ranitidine Bismuth Citrate Versus Omeprazole Plus Two Antibiotics for Seven Days]. An Med Interna. 2001;18(7):361-3. PubMed PMID: 11534420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative study of the eradication of Helicobacter pylori: ranitidine bismuth citrate versus omeprazole plus two antibiotics for seven days]. AU - Bujanda,L, AU - Sánchez,A, AU - Iriondo,C, AU - Santos,A, AU - Cosme,A, AU - Muñoz,C, PY - 2001/9/6/pubmed PY - 2001/10/5/medline PY - 2001/9/6/entrez SP - 361 EP - 3 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 18 IS - 7 N2 - AIMS: To compare the efficacy of ranitidine bismuth citrate (RB) combined with two antibiotics during seven days in comparison with OCA-7 for treatment of Helicobacter pylori. METHODS: In a randomized clinical trial 200, consecutive patients infected by Helicobacter pylori were studied prospectively. One of two regimens was given for 7 days; OCA-7 (omeprazole 20 mg b.i.d., amoxycillin 1 gr b.i.d., clarithromycin 500 mg b.i.d.) or RBCA (RB 400 b.i.d., amoxicillin 1 gr b.i.d., clarithromycin 500 mg b.i.d.). Eradication was defined as a negative breath test one month after therapy. RESULTS: 112 male and 88 female with a mean age of 48 years (range 18-82). 100 patients were randomized to OCA-7 and 100 patients to RBCA-7. Overall 186 patients completed the treatment. Intention to-treat eradication was in the group OCA-7 of 72% and 73% in group RBCA-7. Per-protocol eradication was in the group OCA-7 of 78% and 77% in group RBCA-7 (p = 0.3). Five patients in the group OCA-7 and nine in the group RBCA-7, had side effects, three of these patients did not complete therapy by diarrhea. CONCLUSIONS: RB with two antibiotics is as effective and safe as OCA-7 for the eradication of Helicobacter pylori. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/11534420/[Comparative_study_of_the_eradication_of_Helicobacter_pylori:_ranitidine_bismuth_citrate_versus_omeprazole_plus_two_antibiotics_for_seven_days]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -