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Family history and risk of renal cell carcinoma.

Abstract

Few analytical epidemiological studies have investigated family history (FH) of urinary tract cancers as a potential risk factor for renal cell carcinoma (RCC). A population-based case-control study involving 550 non-Asian RCC patients 25 to 74 years of age and an equal number of sex-, age-, and race-matched neighborhood controls was conducted in Los Angeles, California. Detailed information on FH of cancer, medical and medication histories, and other life-style factors was obtained through in-person interviews. Having a first-degree relative with kidney cancer was associated with a significantly increased risk of RCC [odds ratio (OR), 2.5; 95% confidence interval (CI), 1.04-5.9] after adjustment for potential confounding factors. Having a first and/or second-degree relative with kidney cancer was similarly associated with an increased risk of RCC (OR, 2.9; 95% CI, 1.4-6.3). Risk factors for RCC identified in the Los Angeles study include cigarette smoking, chronic obesity, history of hypertension, regular use of analgesics and amphetamines, intake of cruciferous vegetables (protective), and history of hysterectomy. None of the above risk factor-RCC associations differed significantly between RCC cases with and without a FH of kidney cancer. A FH of urinary tract cancers other than kidney cancer was not associated with RCC risk (OR, 0.7; 95% CI, 0.3-1.7). A FH of nonurinary tract cancers also was unrelated to RCC risk (OR, 1.1; 95% CI, 0.9-1.5).

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, California 90033-0800, USA. mgago@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11535554

Citation

Gago-Dominguez, M, et al. "Family History and Risk of Renal Cell Carcinoma." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 9, 2001, pp. 1001-4.
Gago-Dominguez M, Yuan JM, Castelao JE, et al. Family history and risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2001;10(9):1001-4.
Gago-Dominguez, M., Yuan, J. M., Castelao, J. E., Ross, R. K., & Yu, M. C. (2001). Family history and risk of renal cell carcinoma. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 10(9), pp. 1001-4.
Gago-Dominguez M, et al. Family History and Risk of Renal Cell Carcinoma. Cancer Epidemiol Biomarkers Prev. 2001;10(9):1001-4. PubMed PMID: 11535554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history and risk of renal cell carcinoma. AU - Gago-Dominguez,M, AU - Yuan,J M, AU - Castelao,J E, AU - Ross,R K, AU - Yu,M C, PY - 2001/9/6/pubmed PY - 2001/10/26/medline PY - 2001/9/6/entrez SP - 1001 EP - 4 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 10 IS - 9 N2 - Few analytical epidemiological studies have investigated family history (FH) of urinary tract cancers as a potential risk factor for renal cell carcinoma (RCC). A population-based case-control study involving 550 non-Asian RCC patients 25 to 74 years of age and an equal number of sex-, age-, and race-matched neighborhood controls was conducted in Los Angeles, California. Detailed information on FH of cancer, medical and medication histories, and other life-style factors was obtained through in-person interviews. Having a first-degree relative with kidney cancer was associated with a significantly increased risk of RCC [odds ratio (OR), 2.5; 95% confidence interval (CI), 1.04-5.9] after adjustment for potential confounding factors. Having a first and/or second-degree relative with kidney cancer was similarly associated with an increased risk of RCC (OR, 2.9; 95% CI, 1.4-6.3). Risk factors for RCC identified in the Los Angeles study include cigarette smoking, chronic obesity, history of hypertension, regular use of analgesics and amphetamines, intake of cruciferous vegetables (protective), and history of hysterectomy. None of the above risk factor-RCC associations differed significantly between RCC cases with and without a FH of kidney cancer. A FH of urinary tract cancers other than kidney cancer was not associated with RCC risk (OR, 0.7; 95% CI, 0.3-1.7). A FH of nonurinary tract cancers also was unrelated to RCC risk (OR, 1.1; 95% CI, 0.9-1.5). SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11535554/Family_history_and_risk_of_renal_cell_carcinoma_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11535554 DB - PRIME DP - Unbound Medicine ER -