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Plant foods and risk of gastric cancer: a case-control study in Uruguay.

Abstract

The association between plant foods intake and gastric cancer risk was investigated in a Uruguayan study on environmental factors and cancer. The study included 160 newly diagnosed and histologically verified cases of gastric carcinoma and 320 hospitalized controls. These controls were frequency-matched to the cases on age, sex, residence and urban/rural status. Total vegetable intake was associated with a reduction in risk (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.38-1.08), which was markedly attenuated after adjustment for total fruit intake. The only group of vegetables that persisted as significantly protective after controlling for total energy and total fruit consumption were allium vegetables (OR 0.56, 95% CI 0.34-0.92). On the other hand, total fruit consumption displayed a strong inverse association after controlling for total vegetable intake (OR 0.35, 95% CI 0.21-0.59). Neither tubers nor pulses were associated with gastric cancer risk. Finally, total plant foods were strongly associated with a reduced risk of stomach cancer (OR 0.31, 95% CI 0.18-0.54). It is suggested that vitamins (vitamin C and carotenoids) and bioactive substances (diallyl sulfide) could be involved in the mechanisms of action of plant foods.

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  • Authors+Show Affiliations

    ,

    Registro Nacional de Cáncer, Montevideo, Avda. Brasil 3080 dep. 402, Montevideo, Uruguay.

    , , , , ,

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    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Diet
    Environmental Exposure
    Epidemiologic Studies
    Female
    Fruit
    Humans
    Male
    Middle Aged
    Risk Factors
    Rural Population
    Stomach Neoplasms
    Urban Population
    Uruguay
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11535878

    Citation

    De Stefani, E, et al. "Plant Foods and Risk of Gastric Cancer: a Case-control Study in Uruguay." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 10, no. 4, 2001, pp. 357-64.
    De Stefani E, Correa P, Boffetta P, et al. Plant foods and risk of gastric cancer: a case-control study in Uruguay. Eur J Cancer Prev. 2001;10(4):357-64.
    De Stefani, E., Correa, P., Boffetta, P., Ronco, A., Brennan, P., Deneo-Pellegrini, H., & Mendilaharsu, M. (2001). Plant foods and risk of gastric cancer: a case-control study in Uruguay. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 10(4), pp. 357-64.
    De Stefani E, et al. Plant Foods and Risk of Gastric Cancer: a Case-control Study in Uruguay. Eur J Cancer Prev. 2001;10(4):357-64. PubMed PMID: 11535878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plant foods and risk of gastric cancer: a case-control study in Uruguay. AU - De Stefani,E, AU - Correa,P, AU - Boffetta,P, AU - Ronco,A, AU - Brennan,P, AU - Deneo-Pellegrini,H, AU - Mendilaharsu,M, PY - 2001/9/6/pubmed PY - 2001/9/28/medline PY - 2001/9/6/entrez SP - 357 EP - 64 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 10 IS - 4 N2 - The association between plant foods intake and gastric cancer risk was investigated in a Uruguayan study on environmental factors and cancer. The study included 160 newly diagnosed and histologically verified cases of gastric carcinoma and 320 hospitalized controls. These controls were frequency-matched to the cases on age, sex, residence and urban/rural status. Total vegetable intake was associated with a reduction in risk (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.38-1.08), which was markedly attenuated after adjustment for total fruit intake. The only group of vegetables that persisted as significantly protective after controlling for total energy and total fruit consumption were allium vegetables (OR 0.56, 95% CI 0.34-0.92). On the other hand, total fruit consumption displayed a strong inverse association after controlling for total vegetable intake (OR 0.35, 95% CI 0.21-0.59). Neither tubers nor pulses were associated with gastric cancer risk. Finally, total plant foods were strongly associated with a reduced risk of stomach cancer (OR 0.31, 95% CI 0.18-0.54). It is suggested that vitamins (vitamin C and carotenoids) and bioactive substances (diallyl sulfide) could be involved in the mechanisms of action of plant foods. SN - 0959-8278 UR - https://www.unboundmedicine.com/medline/citation/11535878/Plant_foods_and_risk_of_gastric_cancer:_a_case_control_study_in_Uruguay_ L2 - http://Insights.ovid.com/pubmed?pmid=11535878 DB - PRIME DP - Unbound Medicine ER -