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Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers.
Eur J Cancer Prev 2001; 10(4):365-9EJ

Abstract

The incidence of adenocarcinoma of the oesophagus has increased rapidly in recent decades. In order to appreciate the potential for prevention by means of dietary modification, we estimated the aetiological fractions and the increments in absolute risk attributable to low intake of fruit and vegetables for adenocarcinoma and squamous cell carcinoma of the oesophagus and for adenocarcinoma of the gastroesophageal junction. We conducted a nationwide population-based case-control study in Sweden, with participation of 608 cases and 815 controls. We used unconditional logistic regression to estimate relative risks, from which we calculated aetiological fractions. Individuals in the highest exposure quartile (median 4.8 servings/day) versus the lowest (median 1.5 servings/day) showed approximately 50% lower risk of oesophageal adenocarcinoma and 40% lower risk of oesophageal squamous cell carcinoma, but no risk reduction for gastric cardia adenocarcinoma. Approximately 20% of oesophageal adenocarcinoma, and likewise squamous cell carcinoma, in Sweden was attributed to consuming less than three servings of fruit and vegetables per day. A very large number of individuals (over 25,000) would need to increase their fruit and vegetable consumption moderately in order to prevent one oesophageal cancer per year. Moderate relative risk reductions translate into weak absolute risk reductions for oesophageal cancers in Sweden.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden. paul.terry@mep.ki.se

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11535879

Citation

Terry, P, et al. "Fruit and Vegetable Consumption in the Prevention of Oesophageal and Cardia Cancers." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 10, no. 4, 2001, pp. 365-9.
Terry P, Lagergren J, Hansen H, et al. Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. Eur J Cancer Prev. 2001;10(4):365-9.
Terry, P., Lagergren, J., Hansen, H., Wolk, A., & Nyrén, O. (2001). Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 10(4), pp. 365-9.
Terry P, et al. Fruit and Vegetable Consumption in the Prevention of Oesophageal and Cardia Cancers. Eur J Cancer Prev. 2001;10(4):365-9. PubMed PMID: 11535879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. AU - Terry,P, AU - Lagergren,J, AU - Hansen,H, AU - Wolk,A, AU - Nyrén,O, PY - 2001/9/6/pubmed PY - 2001/9/28/medline PY - 2001/9/6/entrez SP - 365 EP - 9 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 10 IS - 4 N2 - The incidence of adenocarcinoma of the oesophagus has increased rapidly in recent decades. In order to appreciate the potential for prevention by means of dietary modification, we estimated the aetiological fractions and the increments in absolute risk attributable to low intake of fruit and vegetables for adenocarcinoma and squamous cell carcinoma of the oesophagus and for adenocarcinoma of the gastroesophageal junction. We conducted a nationwide population-based case-control study in Sweden, with participation of 608 cases and 815 controls. We used unconditional logistic regression to estimate relative risks, from which we calculated aetiological fractions. Individuals in the highest exposure quartile (median 4.8 servings/day) versus the lowest (median 1.5 servings/day) showed approximately 50% lower risk of oesophageal adenocarcinoma and 40% lower risk of oesophageal squamous cell carcinoma, but no risk reduction for gastric cardia adenocarcinoma. Approximately 20% of oesophageal adenocarcinoma, and likewise squamous cell carcinoma, in Sweden was attributed to consuming less than three servings of fruit and vegetables per day. A very large number of individuals (over 25,000) would need to increase their fruit and vegetable consumption moderately in order to prevent one oesophageal cancer per year. Moderate relative risk reductions translate into weak absolute risk reductions for oesophageal cancers in Sweden. SN - 0959-8278 UR - https://www.unboundmedicine.com/medline/citation/11535879/Fruit_and_vegetable_consumption_in_the_prevention_of_oesophageal_and_cardia_cancers_ L2 - http://Insights.ovid.com/pubmed?pmid=11535879 DB - PRIME DP - Unbound Medicine ER -