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The prognostic significance of microalbuminuria in non-diabetic acute stroke patients.
Med Sci Monit. 2001 Sep-Oct; 7(5):989-94.MS

Abstract

BACKGROUND

Microalbuminuria (MA) is thought to be a marker of widespread vascular damage. It is associated with increased mortality in diabetes mellitus, hypertension and acute myocardial infarction. The aim of the present study was to evaluate the prognostic significance of MA in non-diabetic acute stroke patients.

MATERIAL AND METHODS

We studied 52 patients (mean age 69.3 +/- 12.5 years) diagnosed with ischemic stroke confirmed by computed tomography, who were admitted to the Stroke Unit within 24 hours after the onset of symptoms. The control group consisted of 37 age- and gender-matched subjects (mean age 65.2 +/- 5.7 years), examined 3 to 18 months after ischemic stroke. We excluded patients with diabetes mellitus, positive urinalysis, proteinuria, hepatic or renal insufficiency, neoplastic disease or clinical signs of infection. The severity of the neurological deficit was assessed by the Scandinavian Stroke Scale (SSS). The albumin excretion rate was measured in daily urine collection on the second day of hospitalization, using the immunonephelometric method. The patients were followed up for three months.

RESULTS

MA was found in 24 of 52 (46.1%) acute stroke patients and in 5 of 37 (13.5%) controls (p<0.05). Patients with MA scored lower on the SSS than patients without MA, both on admission and later. We found a correlation between the daily excretion of albumin and the severity of neurological deficit on admission, as expressed by the SSS score (r = -0.48, p<0.05). The 90-day mortality rate was higher in patients with MA as compared to patients without MA (45.8% vs 7.1%). Patients with MA scored lower on the Barthel Index on Day 90 (median: 65 vs 100, p<0.01).

CONCLUSIONS

We found that MA can be detected in about 46% of non-diabetic patients with acute ischemic stroke. Measuring the albumin excretion rate may be a reliable predictor of increased mortality 3 months after stroke.

Authors+Show Affiliations

Department of Neurology, Collegium Medicum, Jagiellonian University, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11535947

Citation

Turaj, W, et al. "The Prognostic Significance of Microalbuminuria in Non-diabetic Acute Stroke Patients." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 7, no. 5, 2001, pp. 989-94.
Turaj W, Słowik A, Wyrwicz-Petkow U, et al. The prognostic significance of microalbuminuria in non-diabetic acute stroke patients. Med Sci Monit. 2001;7(5):989-94.
Turaj, W., Słowik, A., Wyrwicz-Petkow, U., Pankiewicz, J., Iskra, T., Rudzińska, M., & Szczudlik, A. (2001). The prognostic significance of microalbuminuria in non-diabetic acute stroke patients. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 7(5), 989-94.
Turaj W, et al. The Prognostic Significance of Microalbuminuria in Non-diabetic Acute Stroke Patients. Med Sci Monit. 2001 Sep-Oct;7(5):989-94. PubMed PMID: 11535947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic significance of microalbuminuria in non-diabetic acute stroke patients. AU - Turaj,W, AU - Słowik,A, AU - Wyrwicz-Petkow,U, AU - Pankiewicz,J, AU - Iskra,T, AU - Rudzińska,M, AU - Szczudlik,A, PY - 2001/9/6/pubmed PY - 2002/1/18/medline PY - 2001/9/6/entrez SP - 989 EP - 94 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 7 IS - 5 N2 - BACKGROUND: Microalbuminuria (MA) is thought to be a marker of widespread vascular damage. It is associated with increased mortality in diabetes mellitus, hypertension and acute myocardial infarction. The aim of the present study was to evaluate the prognostic significance of MA in non-diabetic acute stroke patients. MATERIAL AND METHODS: We studied 52 patients (mean age 69.3 +/- 12.5 years) diagnosed with ischemic stroke confirmed by computed tomography, who were admitted to the Stroke Unit within 24 hours after the onset of symptoms. The control group consisted of 37 age- and gender-matched subjects (mean age 65.2 +/- 5.7 years), examined 3 to 18 months after ischemic stroke. We excluded patients with diabetes mellitus, positive urinalysis, proteinuria, hepatic or renal insufficiency, neoplastic disease or clinical signs of infection. The severity of the neurological deficit was assessed by the Scandinavian Stroke Scale (SSS). The albumin excretion rate was measured in daily urine collection on the second day of hospitalization, using the immunonephelometric method. The patients were followed up for three months. RESULTS: MA was found in 24 of 52 (46.1%) acute stroke patients and in 5 of 37 (13.5%) controls (p<0.05). Patients with MA scored lower on the SSS than patients without MA, both on admission and later. We found a correlation between the daily excretion of albumin and the severity of neurological deficit on admission, as expressed by the SSS score (r = -0.48, p<0.05). The 90-day mortality rate was higher in patients with MA as compared to patients without MA (45.8% vs 7.1%). Patients with MA scored lower on the Barthel Index on Day 90 (median: 65 vs 100, p<0.01). CONCLUSIONS: We found that MA can be detected in about 46% of non-diabetic patients with acute ischemic stroke. Measuring the albumin excretion rate may be a reliable predictor of increased mortality 3 months after stroke. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/11535947/The_prognostic_significance_of_microalbuminuria_in_non_diabetic_acute_stroke_patients_ L2 - https://www.medscimonit.com/download/index/idArt/432825 DB - PRIME DP - Unbound Medicine ER -