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[Study on mechanisms of T lymphocyte function changes in mice under simulated weightlessness in terms of IL-2 and Bcl-2 gene transcription].
Space Med Med Eng (Beijing). 1998 Aug; 11(4):254-7.SM

Abstract

To understand the mechanisms of T lymphocyte function changes under simulated weightlessness T lymphocyte proliferation (MTT assay), IL-2 production (biological assay), IL-2 gene (dot blot) and Bcl-2 oncogene (RT-PCR) transcription of splenic cell were observed in mice. The results showed that on the 7 th and 14 th day of simulated weightlessness T lymphocyte proliferation and IL-2 production decreased and significant on the 14 th day; on the 7 th and 14 th day of simulated weightlessness IL-2 and Bcl-2 gene transcription decreased, significant on the 14 day. It demonstrated that simulated weightlessness inhibits IL-2 production by decreasing IL-2 gene transcrition. IL-2 and Bcl-2 gene may be regulators of lymphocyte function under simulated weightlessness.

Authors+Show Affiliations

Institute of Space Medico-Engineering, Beijing, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11543242

Citation

Si, S, et al. "[Study On Mechanisms of T Lymphocyte Function Changes in Mice Under Simulated Weightlessness in Terms of IL-2 and Bcl-2 Gene Transcription]." Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, vol. 11, no. 4, 1998, pp. 254-7.
Si S, Wang T, Yang G. [Study on mechanisms of T lymphocyte function changes in mice under simulated weightlessness in terms of IL-2 and Bcl-2 gene transcription]. Space Med Med Eng (Beijing). 1998;11(4):254-7.
Si, S., Wang, T., & Yang, G. (1998). [Study on mechanisms of T lymphocyte function changes in mice under simulated weightlessness in terms of IL-2 and Bcl-2 gene transcription]. Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, 11(4), 254-7.
Si S, Wang T, Yang G. [Study On Mechanisms of T Lymphocyte Function Changes in Mice Under Simulated Weightlessness in Terms of IL-2 and Bcl-2 Gene Transcription]. Space Med Med Eng (Beijing). 1998;11(4):254-7. PubMed PMID: 11543242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on mechanisms of T lymphocyte function changes in mice under simulated weightlessness in terms of IL-2 and Bcl-2 gene transcription]. AU - Si,S, AU - Wang,T, AU - Yang,G, PY - 2001/9/7/pubmed PY - 2001/9/11/medline PY - 2001/9/7/entrez SP - 254 EP - 7 JF - Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering JO - Space Med Med Eng (Beijing) VL - 11 IS - 4 N2 - To understand the mechanisms of T lymphocyte function changes under simulated weightlessness T lymphocyte proliferation (MTT assay), IL-2 production (biological assay), IL-2 gene (dot blot) and Bcl-2 oncogene (RT-PCR) transcription of splenic cell were observed in mice. The results showed that on the 7 th and 14 th day of simulated weightlessness T lymphocyte proliferation and IL-2 production decreased and significant on the 14 th day; on the 7 th and 14 th day of simulated weightlessness IL-2 and Bcl-2 gene transcription decreased, significant on the 14 day. It demonstrated that simulated weightlessness inhibits IL-2 production by decreasing IL-2 gene transcrition. IL-2 and Bcl-2 gene may be regulators of lymphocyte function under simulated weightlessness. SN - 1002-0837 UR - https://www.unboundmedicine.com/medline/citation/11543242/[Study_on_mechanisms_of_T_lymphocyte_function_changes_in_mice_under_simulated_weightlessness_in_terms_of_IL_2_and_Bcl_2_gene_transcription]_ DB - PRIME DP - Unbound Medicine ER -