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Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.
Science 2001; 293(5536):1840-2Sci

Abstract

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

Authors+Show Affiliations

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11546875

Citation

Hatta, M, et al. "Molecular Basis for High Virulence of Hong Kong H5N1 Influenza a Viruses." Science (New York, N.Y.), vol. 293, no. 5536, 2001, pp. 1840-2.
Hatta M, Gao P, Halfmann P, et al. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science. 2001;293(5536):1840-2.
Hatta, M., Gao, P., Halfmann, P., & Kawaoka, Y. (2001). Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (New York, N.Y.), 293(5536), pp. 1840-2.
Hatta M, et al. Molecular Basis for High Virulence of Hong Kong H5N1 Influenza a Viruses. Science. 2001 Sep 7;293(5536):1840-2. PubMed PMID: 11546875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. AU - Hatta,M, AU - Gao,P, AU - Halfmann,P, AU - Kawaoka,Y, PY - 2001/9/8/pubmed PY - 2001/10/5/medline PY - 2001/9/8/entrez SP - 1840 EP - 2 JF - Science (New York, N.Y.) JO - Science VL - 293 IS - 5536 N2 - In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/11546875/Molecular_basis_for_high_virulence_of_Hong_Kong_H5N1_influenza_A_viruses_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11546875 DB - PRIME DP - Unbound Medicine ER -