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Recombination in the hemagglutinin gene of the 1918 "Spanish flu".
Science. 2001 Sep 07; 293(5536):1842-5.Sci

Abstract

When gene sequences from the influenza virus that caused the 1918 pandemic were first compared with those of related viruses, they yielded few clues about its origins and virulence. Our reanalysis indicates that the hemagglutinin gene, a key virulence determinant, originated by recombination. The "globular domain" of the 1918 hemagglutinin protein was encoded by a part of a gene derived from a swine-lineage influenza, whereas the "stalk" was encoded by parts derived from a human-lineage influenza. Phylogenetic analyses showed that this recombination, which probably changed the virulence of the virus, occurred at the start of, or immediately before, the pandemic and thus may have triggered it.

Authors+Show Affiliations

Division of Botany and Zoology, Faculty of Science, Australian National University, Canberra, ACT 2601, Australia. mark.gibbs@anu.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11546876

Citation

Gibbs, M J., et al. "Recombination in the Hemagglutinin Gene of the 1918 "Spanish Flu"." Science (New York, N.Y.), vol. 293, no. 5536, 2001, pp. 1842-5.
Gibbs MJ, Armstrong JS, Gibbs AJ. Recombination in the hemagglutinin gene of the 1918 "Spanish flu". Science. 2001;293(5536):1842-5.
Gibbs, M. J., Armstrong, J. S., & Gibbs, A. J. (2001). Recombination in the hemagglutinin gene of the 1918 "Spanish flu". Science (New York, N.Y.), 293(5536), 1842-5.
Gibbs MJ, Armstrong JS, Gibbs AJ. Recombination in the Hemagglutinin Gene of the 1918 "Spanish Flu". Science. 2001 Sep 7;293(5536):1842-5. PubMed PMID: 11546876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombination in the hemagglutinin gene of the 1918 "Spanish flu". AU - Gibbs,M J, AU - Armstrong,J S, AU - Gibbs,A J, PY - 2001/9/8/pubmed PY - 2001/10/5/medline PY - 2001/9/8/entrez SP - 1842 EP - 5 JF - Science (New York, N.Y.) JO - Science VL - 293 IS - 5536 N2 - When gene sequences from the influenza virus that caused the 1918 pandemic were first compared with those of related viruses, they yielded few clues about its origins and virulence. Our reanalysis indicates that the hemagglutinin gene, a key virulence determinant, originated by recombination. The "globular domain" of the 1918 hemagglutinin protein was encoded by a part of a gene derived from a swine-lineage influenza, whereas the "stalk" was encoded by parts derived from a human-lineage influenza. Phylogenetic analyses showed that this recombination, which probably changed the virulence of the virus, occurred at the start of, or immediately before, the pandemic and thus may have triggered it. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/11546876/Recombination_in_the_hemagglutinin_gene_of_the_1918_"Spanish_flu"_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11546876 DB - PRIME DP - Unbound Medicine ER -