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Predictive risk factors for deterioration from normoglycemic state to type 2 diabetes mellitus or impaired glucose tolerance in a Tunisian urban population.
Diabetes Metab 2001; 27(4 Pt 1):487-95DM

Abstract

OBJECTIVE

To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) or impaired glucose tolerance (IGT) in a normoglycemic population.

RESEARCH DESIGN AND METHODS

This is a ten-year prospective study in a randomly selected urban population including 1835 subjects aged >=30 years living in Tunis, 1460 were normoglycemic according to 2 hours blood glucose WHO criteria, and 701 among them attended the follow-up assessment ten years later. Subjects with impaired glucose tolerance (IGT) were excluded. Subjects underwent a physical examination including weight/height, iliac circumference (IC) and blood pressure measurements. Fasting and 2-hour venous blood sampling, after a 75 g oral glucose load, were performed for the measurement of plasma glucose (G(0), G(2h)), insulin (I(0), I(2h)), total cholesterol (TC) and glycated hemoglobin (HbA(1c)) levels.

RESULTS

Out of the 701 normoglycemic subjects in 1985, 77 developed diabetes and 130 impaired glucose tolerance after 10 years, giving a mean annual incidence rate of 1.1% for diabetes and 1.85% for IGT. Univariate analysis showed that risk factors for diabetes were age, BMI, IC, SBP, G(0) and total cholesterol in both sexes, I(0) and I(2h) in men only and DBP G(2h) and HbA(1c) in women only. Risk factors for IGT were BMI, IC and G(2h) in both sexes, I(2h) in men only and G(0) in women only. Multivariate analysis revealed that BMI, G(0) and G(2h) were independent risk factors for conversion to diabetes or IGT in both sexes, but HbA(1c) and IC were risk factors only in men.

CONCLUSION

Early screening and prevention of diabetes must focus on obese subjects, especially those with central fat distribution, and those with moderate increase in fasting and/or two-hour blood glucose levels within the normal range.

Authors+Show Affiliations

Service d'Endocrinologie-Diabetologie, Hôpital, la Rabta, Tunis.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11547223

Citation

Chihaoui, M, et al. "Predictive Risk Factors for Deterioration From Normoglycemic State to Type 2 Diabetes Mellitus or Impaired Glucose Tolerance in a Tunisian Urban Population." Diabetes & Metabolism, vol. 27, no. 4 Pt 1, 2001, pp. 487-95.
Chihaoui M, Kanoun F, Ben Rehaiem B, et al. Predictive risk factors for deterioration from normoglycemic state to type 2 diabetes mellitus or impaired glucose tolerance in a Tunisian urban population. Diabetes Metab. 2001;27(4 Pt 1):487-95.
Chihaoui, M., Kanoun, F., Ben Rehaiem, B., Ben Brahim, S., Ftouhi, B., Mekaouar, A., ... Ben Khalifa, F. (2001). Predictive risk factors for deterioration from normoglycemic state to type 2 diabetes mellitus or impaired glucose tolerance in a Tunisian urban population. Diabetes & Metabolism, 27(4 Pt 1), pp. 487-95.
Chihaoui M, et al. Predictive Risk Factors for Deterioration From Normoglycemic State to Type 2 Diabetes Mellitus or Impaired Glucose Tolerance in a Tunisian Urban Population. Diabetes Metab. 2001;27(4 Pt 1):487-95. PubMed PMID: 11547223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive risk factors for deterioration from normoglycemic state to type 2 diabetes mellitus or impaired glucose tolerance in a Tunisian urban population. AU - Chihaoui,M, AU - Kanoun,F, AU - Ben Rehaiem,B, AU - Ben Brahim,S, AU - Ftouhi,B, AU - Mekaouar,A, AU - Fekih,M, AU - Mbazâd,A, AU - Zouari,B, AU - Ben Khalifa,F, PY - 2001/9/8/pubmed PY - 2001/10/26/medline PY - 2001/9/8/entrez SP - 487 EP - 95 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 27 IS - 4 Pt 1 N2 - OBJECTIVE: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) or impaired glucose tolerance (IGT) in a normoglycemic population. RESEARCH DESIGN AND METHODS: This is a ten-year prospective study in a randomly selected urban population including 1835 subjects aged >=30 years living in Tunis, 1460 were normoglycemic according to 2 hours blood glucose WHO criteria, and 701 among them attended the follow-up assessment ten years later. Subjects with impaired glucose tolerance (IGT) were excluded. Subjects underwent a physical examination including weight/height, iliac circumference (IC) and blood pressure measurements. Fasting and 2-hour venous blood sampling, after a 75 g oral glucose load, were performed for the measurement of plasma glucose (G(0), G(2h)), insulin (I(0), I(2h)), total cholesterol (TC) and glycated hemoglobin (HbA(1c)) levels. RESULTS: Out of the 701 normoglycemic subjects in 1985, 77 developed diabetes and 130 impaired glucose tolerance after 10 years, giving a mean annual incidence rate of 1.1% for diabetes and 1.85% for IGT. Univariate analysis showed that risk factors for diabetes were age, BMI, IC, SBP, G(0) and total cholesterol in both sexes, I(0) and I(2h) in men only and DBP G(2h) and HbA(1c) in women only. Risk factors for IGT were BMI, IC and G(2h) in both sexes, I(2h) in men only and G(0) in women only. Multivariate analysis revealed that BMI, G(0) and G(2h) were independent risk factors for conversion to diabetes or IGT in both sexes, but HbA(1c) and IC were risk factors only in men. CONCLUSION: Early screening and prevention of diabetes must focus on obese subjects, especially those with central fat distribution, and those with moderate increase in fasting and/or two-hour blood glucose levels within the normal range. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/11547223/Predictive_risk_factors_for_deterioration_from_normoglycemic_state_to_type_2_diabetes_mellitus_or_impaired_glucose_tolerance_in_a_Tunisian_urban_population_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -