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Importance of postprandial glucose control.
South Med J. 2001 Aug; 94(8):804-9.SM

Abstract

Although a traditional goal of glycemic control in the treatment of diabetes mellitus is to normalize fasting plasma glucose, emerging data indicate that modulation of postprandial plasma glucose levels plays an important role in overall glycemic control. This article reviews the evidence linking postprandial glucose levels with long-term indices of diabetes control, such as glycosylated hemoglobin, lipid abnormalities, and the risk of microvascular and macrovascular complications. Early in the development of type 2 diabetes, the initial burst of insulin release in response to food intake is compromised, allowing postprandial hyperglycemia to develop. Meal-associated hyperglycemia further contributes to increase insulin resistance and decrease insulin production. Evidence of a strong correlation between high postprandial glycemic levels and the development of vascular complications underscores the significance of treating mealtime glycemia. Emerging drugs that reduce postprandial hyperglycemia include the D-phenylalanine derivative nateglinide, amylin derivative pramlintide, and glucagon-like insulinotropic peptide.

Authors+Show Affiliations

Department of Medicine, University of Alabama at Birmingham School of Medicine, 35294, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11549192

Citation

Bell, D S.. "Importance of Postprandial Glucose Control." Southern Medical Journal, vol. 94, no. 8, 2001, pp. 804-9.
Bell DS. Importance of postprandial glucose control. South Med J. 2001;94(8):804-9.
Bell, D. S. (2001). Importance of postprandial glucose control. Southern Medical Journal, 94(8), 804-9.
Bell DS. Importance of Postprandial Glucose Control. South Med J. 2001;94(8):804-9. PubMed PMID: 11549192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of postprandial glucose control. A1 - Bell,D S, PY - 2001/9/11/pubmed PY - 2001/9/21/medline PY - 2001/9/11/entrez SP - 804 EP - 9 JF - Southern medical journal JO - South Med J VL - 94 IS - 8 N2 - Although a traditional goal of glycemic control in the treatment of diabetes mellitus is to normalize fasting plasma glucose, emerging data indicate that modulation of postprandial plasma glucose levels plays an important role in overall glycemic control. This article reviews the evidence linking postprandial glucose levels with long-term indices of diabetes control, such as glycosylated hemoglobin, lipid abnormalities, and the risk of microvascular and macrovascular complications. Early in the development of type 2 diabetes, the initial burst of insulin release in response to food intake is compromised, allowing postprandial hyperglycemia to develop. Meal-associated hyperglycemia further contributes to increase insulin resistance and decrease insulin production. Evidence of a strong correlation between high postprandial glycemic levels and the development of vascular complications underscores the significance of treating mealtime glycemia. Emerging drugs that reduce postprandial hyperglycemia include the D-phenylalanine derivative nateglinide, amylin derivative pramlintide, and glucagon-like insulinotropic peptide. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/11549192/Importance_of_postprandial_glucose_control_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11549192.ui DB - PRIME DP - Unbound Medicine ER -