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Epidemiology of the insulin-like growth factor system in three ethnic groups.
Am J Epidemiol 2001; 154(6):504-13AJ

Abstract

The insulin-like growth factor (IGF) system, comprising insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), and their binding proteins (IGFBPs), is linked to cell growth, the development of cardiovascular disease, and several cancers. Little is known about its epidemiology. The authors studied relations of the IGF system to anthropometric and metabolic variables in three population-based ethnic groups in Manchester, England, in 1994-1998 with differing disease risks: African Caribbean (n = 193), Pakistani (n = 130), and local Europeans(n = 142). Standardized anthropometry, glucose tolerance tests, and serum assays were performed. Body mass indices (BMIs) were high in all groups. IGF-I levels were highest in normoglycemic African Caribbeans and declined with age (r = -0.28). IGF-II levels were greatest in Europeans. IGFBP-1 concentrations increased with age in Pakistanis (r = 0.20) and Europeans (r = 0.29), but not in African Caribbeans (r = 0.06), and were inversely related to BMI (r = -0.37). Age- and sex-adjusted IGFBP-1 was inversely related to fasting insulin and proinsulin in all groups; participants with newly detected diabetes were relatively insulinopenic but had higher IGFBP-1 concentrations. Nonesterified (free) fatty acid (NEFA) concentrations increased with declining glucose tolerance. In multiple regression analysis, IGFBP-1 was independently and negatively related to fasting insulin, BMI, and African-Caribbean compared with European ethnicity but positively related to age, fasting glucose, and NEFA. IGF-I was inversely related only to age, NEFA, and Pakistani ethnicity. IGF-II showed a strong ethnic difference but was unrelated to other variables. These data indicate considerable potential for exploring disease-IGF system relations in population samples.

Authors+Show Affiliations

Clinical Epidemiology Group, Unit of Chronic Disease Epidemiology, University of Manchester Medical School, Manchester, England. clinep@man.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11549555

Citation

Cruickshank, J K., et al. "Epidemiology of the Insulin-like Growth Factor System in Three Ethnic Groups." American Journal of Epidemiology, vol. 154, no. 6, 2001, pp. 504-13.
Cruickshank JK, Heald AH, Anderson S, et al. Epidemiology of the insulin-like growth factor system in three ethnic groups. Am J Epidemiol. 2001;154(6):504-13.
Cruickshank, J. K., Heald, A. H., Anderson, S., Cade, J. E., Sampayo, J., Riste, L. K., ... Gibson, J. M. (2001). Epidemiology of the insulin-like growth factor system in three ethnic groups. American Journal of Epidemiology, 154(6), pp. 504-13.
Cruickshank JK, et al. Epidemiology of the Insulin-like Growth Factor System in Three Ethnic Groups. Am J Epidemiol. 2001 Sep 15;154(6):504-13. PubMed PMID: 11549555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of the insulin-like growth factor system in three ethnic groups. AU - Cruickshank,J K, AU - Heald,A H, AU - Anderson,S, AU - Cade,J E, AU - Sampayo,J, AU - Riste,L K, AU - Greenhalgh,A, AU - Taylor,W, AU - Fraser,W, AU - White,A, AU - Gibson,J M, PY - 2001/9/11/pubmed PY - 2001/10/5/medline PY - 2001/9/11/entrez SP - 504 EP - 13 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 154 IS - 6 N2 - The insulin-like growth factor (IGF) system, comprising insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), and their binding proteins (IGFBPs), is linked to cell growth, the development of cardiovascular disease, and several cancers. Little is known about its epidemiology. The authors studied relations of the IGF system to anthropometric and metabolic variables in three population-based ethnic groups in Manchester, England, in 1994-1998 with differing disease risks: African Caribbean (n = 193), Pakistani (n = 130), and local Europeans(n = 142). Standardized anthropometry, glucose tolerance tests, and serum assays were performed. Body mass indices (BMIs) were high in all groups. IGF-I levels were highest in normoglycemic African Caribbeans and declined with age (r = -0.28). IGF-II levels were greatest in Europeans. IGFBP-1 concentrations increased with age in Pakistanis (r = 0.20) and Europeans (r = 0.29), but not in African Caribbeans (r = 0.06), and were inversely related to BMI (r = -0.37). Age- and sex-adjusted IGFBP-1 was inversely related to fasting insulin and proinsulin in all groups; participants with newly detected diabetes were relatively insulinopenic but had higher IGFBP-1 concentrations. Nonesterified (free) fatty acid (NEFA) concentrations increased with declining glucose tolerance. In multiple regression analysis, IGFBP-1 was independently and negatively related to fasting insulin, BMI, and African-Caribbean compared with European ethnicity but positively related to age, fasting glucose, and NEFA. IGF-I was inversely related only to age, NEFA, and Pakistani ethnicity. IGF-II showed a strong ethnic difference but was unrelated to other variables. These data indicate considerable potential for exploring disease-IGF system relations in population samples. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/11549555/Epidemiology_of_the_insulin_like_growth_factor_system_in_three_ethnic_groups_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/154.6.504 DB - PRIME DP - Unbound Medicine ER -