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Coeliac disease in patients with autoimmune thyroiditis.

Abstract

BACKGROUND AND AIMS

The close association between coeliac disease and autoimmunity prompted us to perform an antibody screening for gluten-sensitive enteropathy in patients with autoimmune thyroid dysfunction.

METHODS

Sera from 220 patients with autoimmune thyroiditis, 50 euthyroid subjects with thyroid nodules and 250 blood donors were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA).

RESULTS

IgA anti-tTG was positive in 7 patients with autoimmune thyroiditis, whereas IgA EmA was found only in 6 of them. Duodenal biopsy confirmed coeliac disease diagnosis disclosing marked and mild villous atrophy in 6 and 1 of them, respectively. All but 2 of the 7 coeliacs did not show any sign of malabsorption. All euthyroid controls were negative for IgA antibodies, whereas 1 blood donor, positive for both IgA anti-tTG and EmA, was found to be coeliac. The prevalence of coeliac disease in patients with autoimmune thyroiditis (3.2%) was significantly higher than that found in blood donors (0.4%) (p = 0.022, Fisher's exact test).

CONCLUSIONS

Antibody screening for coeliac disease should be included in the work-up of patients with autoimmune thyroiditis. Either IgA anti-tTG or EmA may be used, even though the former seems to be slightly more sensitive than the latter.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, S. Orsola-Malpighi Polyclinic, Bologna, Italy. uvolta@orsola-malpighi.med.unibo.it

    , , , , , ,

    Source

    Digestion 64:1 2001 pg 61-5

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Autoantibodies
    Celiac Disease
    Duodenum
    Female
    Humans
    Immunoglobulin A
    Intestinal Mucosa
    Male
    Middle Aged
    Prevalence
    Thyroiditis, Autoimmune
    Transglutaminases

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    11549838

    Citation

    Volta, U, et al. "Coeliac Disease in Patients With Autoimmune Thyroiditis." Digestion, vol. 64, no. 1, 2001, pp. 61-5.
    Volta U, Ravaglia G, Granito A, et al. Coeliac disease in patients with autoimmune thyroiditis. Digestion. 2001;64(1):61-5.
    Volta, U., Ravaglia, G., Granito, A., Forti, P., Maioli, F., Petrolini, N., ... Bianchi, F. B. (2001). Coeliac disease in patients with autoimmune thyroiditis. Digestion, 64(1), pp. 61-5.
    Volta U, et al. Coeliac Disease in Patients With Autoimmune Thyroiditis. Digestion. 2001;64(1):61-5. PubMed PMID: 11549838.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coeliac disease in patients with autoimmune thyroiditis. AU - Volta,U, AU - Ravaglia,G, AU - Granito,A, AU - Forti,P, AU - Maioli,F, AU - Petrolini,N, AU - Zoli,M, AU - Bianchi,F B, PY - 2001/9/11/pubmed PY - 2003/1/3/medline PY - 2001/9/11/entrez SP - 61 EP - 5 JF - Digestion JO - Digestion VL - 64 IS - 1 N2 - BACKGROUND AND AIMS: The close association between coeliac disease and autoimmunity prompted us to perform an antibody screening for gluten-sensitive enteropathy in patients with autoimmune thyroid dysfunction. METHODS: Sera from 220 patients with autoimmune thyroiditis, 50 euthyroid subjects with thyroid nodules and 250 blood donors were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). RESULTS: IgA anti-tTG was positive in 7 patients with autoimmune thyroiditis, whereas IgA EmA was found only in 6 of them. Duodenal biopsy confirmed coeliac disease diagnosis disclosing marked and mild villous atrophy in 6 and 1 of them, respectively. All but 2 of the 7 coeliacs did not show any sign of malabsorption. All euthyroid controls were negative for IgA antibodies, whereas 1 blood donor, positive for both IgA anti-tTG and EmA, was found to be coeliac. The prevalence of coeliac disease in patients with autoimmune thyroiditis (3.2%) was significantly higher than that found in blood donors (0.4%) (p = 0.022, Fisher's exact test). CONCLUSIONS: Antibody screening for coeliac disease should be included in the work-up of patients with autoimmune thyroiditis. Either IgA anti-tTG or EmA may be used, even though the former seems to be slightly more sensitive than the latter. SN - 0012-2823 UR - https://www.unboundmedicine.com/medline/citation/11549838/Coeliac_disease_in_patients_with_autoimmune_thyroiditis_ L2 - https://www.karger.com?DOI=10.1159/000048840 DB - PRIME DP - Unbound Medicine ER -