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Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy.
Clin Lab Haematol. 2001 Jun; 23(3):161-5.CL

Abstract

Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy.

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Authors+Show Affiliations

McMullin MF
Department of Haematology, The Queen's University of Belfast, Belfast, UK. m.mcmullin@qub.ac.uk
Young PB
No affiliation info available
Bailie KE
No affiliation info available
Savage GA
No affiliation info available
Lappin TR
No affiliation info available
White R
No affiliation info available

MeSH

AdultBiomarkersFemaleFolic Acid DeficiencyHomocysteineHumansMethylmalonic AcidPregnancyPregnancy ComplicationsVitamin B 12 Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11553056

Citation

McMullin, M F., et al. "Homocysteine and Methylmalonic Acid as Indicators of Folate and Vitamin B12 Deficiency in Pregnancy." Clinical and Laboratory Haematology, vol. 23, no. 3, 2001, pp. 161-5.
McMullin MF, Young PB, Bailie KE, et al. Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy. Clin Lab Haematol. 2001;23(3):161-5.
McMullin, M. F., Young, P. B., Bailie, K. E., Savage, G. A., Lappin, T. R., & White, R. (2001). Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy. Clinical and Laboratory Haematology, 23(3), 161-5.
McMullin MF, et al. Homocysteine and Methylmalonic Acid as Indicators of Folate and Vitamin B12 Deficiency in Pregnancy. Clin Lab Haematol. 2001;23(3):161-5. PubMed PMID: 11553056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy. AU - McMullin,M F, AU - Young,P B, AU - Bailie,K E, AU - Savage,G A, AU - Lappin,T R, AU - White,R, PY - 2001/9/13/pubmed PY - 2002/7/3/medline PY - 2001/9/13/entrez SP - 161 EP - 5 JF - Clinical and laboratory haematology JO - Clin Lab Haematol VL - 23 IS - 3 N2 - Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy. SN - 0141-9854 UR - https://www.unboundmedicine.com/medline/citation/11553056/Homocysteine_and_methylmalonic_acid_as_indicators_of_folate_and_vitamin_B12_deficiency_in_pregnancy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9854&date=2001&volume=23&issue=3&spage=161 DB - PRIME DP - Unbound Medicine ER -