Tags

Type your tag names separated by a space and hit enter

Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia.
Am J Clin Pathol. 2001 Sep; 116(3):437-43.AJ

Abstract

Differential expression of CD20 surface antigen in B-cell neoplasms at different sites is largely unknown. The number of CD20 antibodies bound per cell (CD20 ABC) in bone marrow (BM), peripheral blood (PB), and lymph node aspirate (LNA) samples from patients with B-cell chronic lymphocytic leukemia (B-CLL) or other B-cell disease was studied using quantitative flow cytometry. CD20 ABC differed significantly with the specimen type in B-CLL, being highest in PB (mean, 9,051) and lower in BM (mean, 4,067) and LNA (mean, 3,951). No difference in CD20 ABC between BM and PB samples was found in splenic lymphoma, mantle cell lymphoma, or follicular lymphoma. Also, we found a significant difference of CD20 ABC by type of disease: lowest in B-CLL; higher in splenic, follicular, and mantle cell lymphoma; and highest in hairy cell leukemia. The lower CD20 surface antigen levels in BM and LNA than in PB in B-CLL may have clinical relevance with regard to the efficacy of rituximab therapy.

Authors+Show Affiliations

Departments of Hematopathology and Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11554173

Citation

Huh, Y O., et al. "Higher Levels of Surface CD20 Expression On Circulating Lymphocytes Compared With Bone Marrow and Lymph Nodes in B-cell Chronic Lymphocytic Leukemia." American Journal of Clinical Pathology, vol. 116, no. 3, 2001, pp. 437-43.
Huh YO, Keating MJ, Saffer HL, et al. Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. Am J Clin Pathol. 2001;116(3):437-43.
Huh, Y. O., Keating, M. J., Saffer, H. L., Jilani, I., Lerner, S., & Albitar, M. (2001). Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. American Journal of Clinical Pathology, 116(3), 437-43.
Huh YO, et al. Higher Levels of Surface CD20 Expression On Circulating Lymphocytes Compared With Bone Marrow and Lymph Nodes in B-cell Chronic Lymphocytic Leukemia. Am J Clin Pathol. 2001;116(3):437-43. PubMed PMID: 11554173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. AU - Huh,Y O, AU - Keating,M J, AU - Saffer,H L, AU - Jilani,I, AU - Lerner,S, AU - Albitar,M, PY - 2001/9/14/pubmed PY - 2001/9/28/medline PY - 2001/9/14/entrez SP - 437 EP - 43 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 116 IS - 3 N2 - Differential expression of CD20 surface antigen in B-cell neoplasms at different sites is largely unknown. The number of CD20 antibodies bound per cell (CD20 ABC) in bone marrow (BM), peripheral blood (PB), and lymph node aspirate (LNA) samples from patients with B-cell chronic lymphocytic leukemia (B-CLL) or other B-cell disease was studied using quantitative flow cytometry. CD20 ABC differed significantly with the specimen type in B-CLL, being highest in PB (mean, 9,051) and lower in BM (mean, 4,067) and LNA (mean, 3,951). No difference in CD20 ABC between BM and PB samples was found in splenic lymphoma, mantle cell lymphoma, or follicular lymphoma. Also, we found a significant difference of CD20 ABC by type of disease: lowest in B-CLL; higher in splenic, follicular, and mantle cell lymphoma; and highest in hairy cell leukemia. The lower CD20 surface antigen levels in BM and LNA than in PB in B-CLL may have clinical relevance with regard to the efficacy of rituximab therapy. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/11554173/Higher_levels_of_surface_CD20_expression_on_circulating_lymphocytes_compared_with_bone_marrow_and_lymph_nodes_in_B_cell_chronic_lymphocytic_leukemia_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/438N-E0FH-A5PR-XCAC DB - PRIME DP - Unbound Medicine ER -