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Tumour markers in breast carcinoma correlate with grade rather than with invasiveness.
Br J Cancer. 2001 Sep 14; 85(6):869-74.BJ

Abstract

Ductal breast carcinoma in situ (DCIS) is regarded as a precursor to invasive breast cancer. The progression from in situ to invasive cancer is however little understood. We compared some tumour markers in invasive and in situ breast carcinomas trying to find steps in this progression. We designed a semi-experimental setting and compared histopathological grading and tumour marker expression in pure DCIS (n = 194), small invasive lesions (n = 127) and lesions with both an invasive and in situ component (n = 305). Grading was done according to the Elston-Ellis and EORTC classification systems, respectively. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, ER, PR, bcl-2 and angiogenesis. All markers correlated with grade rather than with invasiveness. No marker was clearly associated with the progression from in situ to invasiveness. The expression of tumour markers was almost identical in the 2 components of mixed lesions. DCIS as a group showed a more 'malignant picture' than invasive cancer according to the markers, probably, due to a higher proportion of poorly differentiated lesions. The step between in situ and invasive cancer seems to occur independently of tumour grade. The results suggest that well-differentiated DCIS progress to well-differentiated invasive cancer and poorly differentiated DCIS progress to poorly differentiated invasive cancer.

Authors+Show Affiliations

Department of Surgery, University Hospital Uppsala, S-751 85 Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11556839

Citation

Wärnberg, F, et al. "Tumour Markers in Breast Carcinoma Correlate With Grade Rather Than With Invasiveness." British Journal of Cancer, vol. 85, no. 6, 2001, pp. 869-74.
Wärnberg F, Nordgren H, Bergkvist L, et al. Tumour markers in breast carcinoma correlate with grade rather than with invasiveness. Br J Cancer. 2001;85(6):869-74.
Wärnberg, F., Nordgren, H., Bergkvist, L., & Holmberg, L. (2001). Tumour markers in breast carcinoma correlate with grade rather than with invasiveness. British Journal of Cancer, 85(6), 869-74.
Wärnberg F, et al. Tumour Markers in Breast Carcinoma Correlate With Grade Rather Than With Invasiveness. Br J Cancer. 2001 Sep 14;85(6):869-74. PubMed PMID: 11556839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumour markers in breast carcinoma correlate with grade rather than with invasiveness. AU - Wärnberg,F, AU - Nordgren,H, AU - Bergkvist,L, AU - Holmberg,L, PY - 2001/9/15/pubmed PY - 2001/11/3/medline PY - 2001/9/15/entrez SP - 869 EP - 74 JF - British journal of cancer JO - Br J Cancer VL - 85 IS - 6 N2 - Ductal breast carcinoma in situ (DCIS) is regarded as a precursor to invasive breast cancer. The progression from in situ to invasive cancer is however little understood. We compared some tumour markers in invasive and in situ breast carcinomas trying to find steps in this progression. We designed a semi-experimental setting and compared histopathological grading and tumour marker expression in pure DCIS (n = 194), small invasive lesions (n = 127) and lesions with both an invasive and in situ component (n = 305). Grading was done according to the Elston-Ellis and EORTC classification systems, respectively. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, ER, PR, bcl-2 and angiogenesis. All markers correlated with grade rather than with invasiveness. No marker was clearly associated with the progression from in situ to invasiveness. The expression of tumour markers was almost identical in the 2 components of mixed lesions. DCIS as a group showed a more 'malignant picture' than invasive cancer according to the markers, probably, due to a higher proportion of poorly differentiated lesions. The step between in situ and invasive cancer seems to occur independently of tumour grade. The results suggest that well-differentiated DCIS progress to well-differentiated invasive cancer and poorly differentiated DCIS progress to poorly differentiated invasive cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/11556839/Tumour_markers_in_breast_carcinoma_correlate_with_grade_rather_than_with_invasiveness_ L2 - https://doi.org/10.1054/bjoc.2001.1995 DB - PRIME DP - Unbound Medicine ER -