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In vitro activity of the ketolide ABT-773.
Antimicrob Agents Chemother. 2001 Oct; 45(10):2922-4.AA

Abstract

The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC(90)] was < or =0.06 microg/ml), including all strains that were macrolide resistant but clindamycin susceptible. Streptococcus pneumoniae and other streptococci were inhibited by low concentrations of ABT-773, and that included most erythromycin-resistant strains. Against Haemophilus influenzae, ABT-773 and azithromycin were similar in their antibacterial potency (MIC(90), 4.0 and 2.0 microg/ml, respectively).

Links

Publisher Full Text
ncbi.nlm.nih.gov
journals.asm.org
PMC Free PDF

Authors+Show Affiliations

Barry AL
The Clinical Microbiology Institute, 9725 S.W. Commerce Circle, Wilsonville, OR 97070, USA. cmi@hevanet.com
Fuchs PC
No affiliation info available
Brown SD
No affiliation info available

MeSH

Drug Resistance, BacterialErythromycinHaemophilus influenzaeHumansKetolidesMicrobial Sensitivity TestsStreptococcus pneumoniae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11557491

Clinical Trial Links

Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis

Citation

Barry, A L., et al. "In Vitro Activity of the Ketolide ABT-773." Antimicrobial Agents and Chemotherapy, vol. 45, no. 10, 2001, pp. 2922-4.
Barry AL, Fuchs PC, Brown SD. In vitro activity of the ketolide ABT-773. Antimicrob Agents Chemother. 2001;45(10):2922-4.
Barry, A. L., Fuchs, P. C., & Brown, S. D. (2001). In vitro activity of the ketolide ABT-773. Antimicrobial Agents and Chemotherapy, 45(10), 2922-4.
Barry AL, Fuchs PC, Brown SD. In Vitro Activity of the Ketolide ABT-773. Antimicrob Agents Chemother. 2001;45(10):2922-4. PubMed PMID: 11557491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of the ketolide ABT-773. AU - Barry,A L, AU - Fuchs,P C, AU - Brown,S D, PY - 2001/9/15/pubmed PY - 2002/1/5/medline PY - 2001/9/15/entrez SP - 2922 EP - 4 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 45 IS - 10 N2 - The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC(90)] was < or =0.06 microg/ml), including all strains that were macrolide resistant but clindamycin susceptible. Streptococcus pneumoniae and other streptococci were inhibited by low concentrations of ABT-773, and that included most erythromycin-resistant strains. Against Haemophilus influenzae, ABT-773 and azithromycin were similar in their antibacterial potency (MIC(90), 4.0 and 2.0 microg/ml, respectively). SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/11557491/In_vitro_activity_of_the_ketolide_ABT_773_ L2 - https://journals.asm.org/doi/10.1128/AAC.45.10.2922-2924.2001?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -