Tags

Type your tag names separated by a space and hit enter

Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece.
J Glaucoma. 2001 Aug; 10(4):316-24.JG

Abstract

PURPOSE

To compare the intraocular pressure-lowering effect of latanoprost with that of dorzolamide when added to timolol.

PATIENTS AND METHODS

This randomized, open-label study with two parallel groups was conducted in five centers in Greece. The study enrolled 148 patients with inadequately controlled open-angle or pseudoexfoliation glaucoma (intraocular pressure of at least 22 mm Hg) or ocular hypertension (intraocular pressure of at least 27 mm Hg) who were receiving monotherapy with a beta-blocker or dual therapy in which one of the agents was a beta-blocker. The patients were switched to timolol 0.5% twice daily for 2 to 4 weeks (run-in period) before the start of the study (baseline). At baseline, the patients were randomized to receive latanoprost 0.005% once daily or dorzolamide 2% twice daily as add-on therapy to timolol. The intraocular pressure was recorded at 9:30 AM, 12:30 PM, and 3:30 PM at baseline and at 3 months. Safety was followed throughout the study.

RESULTS

The diurnal intraocular pressure reduction was significant in both groups (P < 0.001). The mean intraocular pressure reduction from baseline was 32% for the latanoprost plus timolol group and 20% for the dorzolamide plus timolol group. The least square estimate of the mean diurnal intraocular pressure reduction after 3 months was -7.06 mm Hg in the latanoprost plus timolol group and -4.44 mm Hg in the dorzolamide plus timolol group (P < 0.001). Drugs administered in both treatment groups were well tolerated.

CONCLUSION

This study clearly showed that the additive diurnal intraocular pressure-lowering effect of latanoprost is superior to that of dorzolamide in patients treated with timolol.

Authors+Show Affiliations

Department of Ophthalmology, Patissia General Hospital, Athens, Greece. andre_petounis@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11558817

Citation

Petounis, A, et al. "Comparison of the Additive Intraocular Pressure-lowering Effect of Latanoprost and Dorzolamide when Added to Timolol in Patients With Open-angle Glaucoma or Ocular Hypertension: a Randomized, Open-label, Multicenter Study in Greece." Journal of Glaucoma, vol. 10, no. 4, 2001, pp. 316-24.
Petounis A, Mylopoulos N, Kandarakis A, et al. Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece. J Glaucoma. 2001;10(4):316-24.
Petounis, A., Mylopoulos, N., Kandarakis, A., Andreanos, D., & Dimitrakoulias, N. (2001). Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece. Journal of Glaucoma, 10(4), 316-24.
Petounis A, et al. Comparison of the Additive Intraocular Pressure-lowering Effect of Latanoprost and Dorzolamide when Added to Timolol in Patients With Open-angle Glaucoma or Ocular Hypertension: a Randomized, Open-label, Multicenter Study in Greece. J Glaucoma. 2001;10(4):316-24. PubMed PMID: 11558817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece. AU - Petounis,A, AU - Mylopoulos,N, AU - Kandarakis,A, AU - Andreanos,D, AU - Dimitrakoulias,N, PY - 2001/9/18/pubmed PY - 2002/1/15/medline PY - 2001/9/18/entrez SP - 316 EP - 24 JF - Journal of glaucoma JO - J. Glaucoma VL - 10 IS - 4 N2 - PURPOSE: To compare the intraocular pressure-lowering effect of latanoprost with that of dorzolamide when added to timolol. PATIENTS AND METHODS: This randomized, open-label study with two parallel groups was conducted in five centers in Greece. The study enrolled 148 patients with inadequately controlled open-angle or pseudoexfoliation glaucoma (intraocular pressure of at least 22 mm Hg) or ocular hypertension (intraocular pressure of at least 27 mm Hg) who were receiving monotherapy with a beta-blocker or dual therapy in which one of the agents was a beta-blocker. The patients were switched to timolol 0.5% twice daily for 2 to 4 weeks (run-in period) before the start of the study (baseline). At baseline, the patients were randomized to receive latanoprost 0.005% once daily or dorzolamide 2% twice daily as add-on therapy to timolol. The intraocular pressure was recorded at 9:30 AM, 12:30 PM, and 3:30 PM at baseline and at 3 months. Safety was followed throughout the study. RESULTS: The diurnal intraocular pressure reduction was significant in both groups (P < 0.001). The mean intraocular pressure reduction from baseline was 32% for the latanoprost plus timolol group and 20% for the dorzolamide plus timolol group. The least square estimate of the mean diurnal intraocular pressure reduction after 3 months was -7.06 mm Hg in the latanoprost plus timolol group and -4.44 mm Hg in the dorzolamide plus timolol group (P < 0.001). Drugs administered in both treatment groups were well tolerated. CONCLUSION: This study clearly showed that the additive diurnal intraocular pressure-lowering effect of latanoprost is superior to that of dorzolamide in patients treated with timolol. SN - 1057-0829 UR - https://www.unboundmedicine.com/medline/citation/11558817/Comparison_of_the_additive_intraocular_pressure_lowering_effect_of_latanoprost_and_dorzolamide_when_added_to_timolol_in_patients_with_open_angle_glaucoma_or_ocular_hypertension:_a_randomized_open_label_multicenter_study_in_Greece_ L2 - http://dx.doi.org/10.1097/00061198-200108000-00012 DB - PRIME DP - Unbound Medicine ER -