Tags

Type your tag names separated by a space and hit enter

Risk factors for basal cell carcinoma in a Mediterranean population: role of recreational sun exposure early in life.

Abstract

OBJECTIVE

To investigate the role of pigmentary traits, different patterns of sun exposure, artificial sources of UV radiation, and lifestyle-related factors on the risk of basal cell carcinoma (BCC) in a Mediterranean population from central-southern Italy.

DESIGN

Hospital-based case-control study.

SETTING

A referral dermatological hospital in Rome, Italy.

PATIENTS

A convenience sample of 166 case patients with histologically confirmed BCC and 158 cancer-free control subjects with minor dermatological conditions observed between March 1995 and June 1997.

RESULTS

In the multivariate analysis, the mean number of weeks per year spent at the beach before the age of 20 years was significantly associated with BCC. A dose-response trend was found for subjects who had spent 3 to 4 (odds ratio, 1.8; 95% confidence interval, 0.8-4.4), 5 to 8 (odds ratio, 3.7; 95% confidence interval, 1.5-9.0), or more than 8 (odds ratio, 4.5; 95% confidence interval, 1.9-10.5) weeks per year at the beach (P =.01 for trend). There was a significant association with the presence of actinic keratoses or solar lentigines, whereas no effect was found for skin type, history of sunburns, exposure to nonsolar UV radiation, and lifestyle-related habits such as cigarette smoking, alcohol consumption, and coffee drinking. Subjects reporting a family history of skin cancer had an extremely increased risk of BCC.

CONCLUSION

The definite association with recreational sun exposure during childhood and adolescence and the strong relation with family history of skin cancer suggest that genetic predisposition and peculiar exposure patterns to UV radiation are key independent risk factors for the development of BCC in a southern European population.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Istituto Dermopatico dell'Immacolata, Via dei Monti di Creta 104, 00167 Rome, Italy. r.corona@idi.it

    , , , , , , , , ,

    Source

    Archives of dermatology 137:9 2001 Sep pg 1162-8

    MeSH

    Adolescent
    Adult
    Aged
    Carcinoma, Basal Cell
    Confidence Intervals
    Dose-Response Relationship, Radiation
    Ethnic Groups
    Female
    Humans
    Italy
    Life Style
    Male
    Middle Aged
    Neoplasms, Radiation-Induced
    Odds Ratio
    Recreation
    Risk Factors
    Skin Neoplasms
    Skin Pigmentation
    Sunlight
    Ultraviolet Rays

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11559211

    Citation

    Corona, R, et al. "Risk Factors for Basal Cell Carcinoma in a Mediterranean Population: Role of Recreational Sun Exposure Early in Life." Archives of Dermatology, vol. 137, no. 9, 2001, pp. 1162-8.
    Corona R, Dogliotti E, D'Errico M, et al. Risk factors for basal cell carcinoma in a Mediterranean population: role of recreational sun exposure early in life. Arch Dermatol. 2001;137(9):1162-8.
    Corona, R., Dogliotti, E., D'Errico, M., Sera, F., Iavarone, I., Baliva, G., ... Pasquini, P. (2001). Risk factors for basal cell carcinoma in a Mediterranean population: role of recreational sun exposure early in life. Archives of Dermatology, 137(9), pp. 1162-8.
    Corona R, et al. Risk Factors for Basal Cell Carcinoma in a Mediterranean Population: Role of Recreational Sun Exposure Early in Life. Arch Dermatol. 2001;137(9):1162-8. PubMed PMID: 11559211.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk factors for basal cell carcinoma in a Mediterranean population: role of recreational sun exposure early in life. AU - Corona,R, AU - Dogliotti,E, AU - D'Errico,M, AU - Sera,F, AU - Iavarone,I, AU - Baliva,G, AU - Chinni,L M, AU - Gobello,T, AU - Mazzanti,C, AU - Puddu,P, AU - Pasquini,P, PY - 2001/9/18/pubmed PY - 2001/10/5/medline PY - 2001/9/18/entrez SP - 1162 EP - 8 JF - Archives of dermatology JO - Arch Dermatol VL - 137 IS - 9 N2 - OBJECTIVE: To investigate the role of pigmentary traits, different patterns of sun exposure, artificial sources of UV radiation, and lifestyle-related factors on the risk of basal cell carcinoma (BCC) in a Mediterranean population from central-southern Italy. DESIGN: Hospital-based case-control study. SETTING: A referral dermatological hospital in Rome, Italy. PATIENTS: A convenience sample of 166 case patients with histologically confirmed BCC and 158 cancer-free control subjects with minor dermatological conditions observed between March 1995 and June 1997. RESULTS: In the multivariate analysis, the mean number of weeks per year spent at the beach before the age of 20 years was significantly associated with BCC. A dose-response trend was found for subjects who had spent 3 to 4 (odds ratio, 1.8; 95% confidence interval, 0.8-4.4), 5 to 8 (odds ratio, 3.7; 95% confidence interval, 1.5-9.0), or more than 8 (odds ratio, 4.5; 95% confidence interval, 1.9-10.5) weeks per year at the beach (P =.01 for trend). There was a significant association with the presence of actinic keratoses or solar lentigines, whereas no effect was found for skin type, history of sunburns, exposure to nonsolar UV radiation, and lifestyle-related habits such as cigarette smoking, alcohol consumption, and coffee drinking. Subjects reporting a family history of skin cancer had an extremely increased risk of BCC. CONCLUSION: The definite association with recreational sun exposure during childhood and adolescence and the strong relation with family history of skin cancer suggest that genetic predisposition and peculiar exposure patterns to UV radiation are key independent risk factors for the development of BCC in a southern European population. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/11559211/Risk_factors_for_basal_cell_carcinoma_in_a_Mediterranean_population:_role_of_recreational_sun_exposure_early_in_life_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/137/pg/1162 DB - PRIME DP - Unbound Medicine ER -