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Suckling stimulus suppresses messenger RNA for tyrosine hydroxylase in arcuate neurons during lactation.
J Comp Neurol. 2001 Oct 01; 438(4):423-32.JC

Abstract

Tyrosine hydroxylase (TH) mRNA in tuberoinfundibular dopamine (TIDA) neurons is suppressed during lactation but rebounds upon pup removal. A time course of TH mRNA changes after pup removal revealed three phases: (1) a nuclear phase (evident 1.5 hours after pup removal, maximal at 3 hours) with TH mRNA appearing in 1 or 2 nuclear loci with little or no change in cytoplasmic mRNA; (2) a cytoplasmic phase (noted 6 hours after pup removal, peaked 12-24 hours) with a significant increase in total TH mRNA levels mainly in the cytoplasm; and (3) a stabilization phase (24-48 hours after pup removal) when nuclear signals were low and cytoplasmic RNA showed a slight decline with extension of RNA clusters into the cell dendrites. In rats whose pups could suckle only on one side, TH was up-regulated only on the side contralateral to nipple blockade. These data indicate that after suckling terminates, TH up-regulation is evident at 1.5 hours, but 6 hours is needed before the cells transport sufficient mRNA into the cytoplasm. The rapid signaling of TH up-regulation stems from the fact that the TIDA neurons respond to neural signals from termination of suckling.

Authors+Show Affiliations

Laboratory for Pregnancy and Newborn Research, Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11559898

Citation

Berghorn, K A., et al. "Suckling Stimulus Suppresses Messenger RNA for Tyrosine Hydroxylase in Arcuate Neurons During Lactation." The Journal of Comparative Neurology, vol. 438, no. 4, 2001, pp. 423-32.
Berghorn KA, Le WW, Sherman TG, et al. Suckling stimulus suppresses messenger RNA for tyrosine hydroxylase in arcuate neurons during lactation. J Comp Neurol. 2001;438(4):423-32.
Berghorn, K. A., Le, W. W., Sherman, T. G., & Hoffman, G. E. (2001). Suckling stimulus suppresses messenger RNA for tyrosine hydroxylase in arcuate neurons during lactation. The Journal of Comparative Neurology, 438(4), 423-32.
Berghorn KA, et al. Suckling Stimulus Suppresses Messenger RNA for Tyrosine Hydroxylase in Arcuate Neurons During Lactation. J Comp Neurol. 2001 Oct 1;438(4):423-32. PubMed PMID: 11559898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suckling stimulus suppresses messenger RNA for tyrosine hydroxylase in arcuate neurons during lactation. AU - Berghorn,K A, AU - Le,W W, AU - Sherman,T G, AU - Hoffman,G E, PY - 2001/9/18/pubmed PY - 2001/10/26/medline PY - 2001/9/18/entrez SP - 423 EP - 32 JF - The Journal of comparative neurology JO - J Comp Neurol VL - 438 IS - 4 N2 - Tyrosine hydroxylase (TH) mRNA in tuberoinfundibular dopamine (TIDA) neurons is suppressed during lactation but rebounds upon pup removal. A time course of TH mRNA changes after pup removal revealed three phases: (1) a nuclear phase (evident 1.5 hours after pup removal, maximal at 3 hours) with TH mRNA appearing in 1 or 2 nuclear loci with little or no change in cytoplasmic mRNA; (2) a cytoplasmic phase (noted 6 hours after pup removal, peaked 12-24 hours) with a significant increase in total TH mRNA levels mainly in the cytoplasm; and (3) a stabilization phase (24-48 hours after pup removal) when nuclear signals were low and cytoplasmic RNA showed a slight decline with extension of RNA clusters into the cell dendrites. In rats whose pups could suckle only on one side, TH was up-regulated only on the side contralateral to nipple blockade. These data indicate that after suckling terminates, TH up-regulation is evident at 1.5 hours, but 6 hours is needed before the cells transport sufficient mRNA into the cytoplasm. The rapid signaling of TH up-regulation stems from the fact that the TIDA neurons respond to neural signals from termination of suckling. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/11559898/Suckling_stimulus_suppresses_messenger_RNA_for_tyrosine_hydroxylase_in_arcuate_neurons_during_lactation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0021-9967&date=2001&volume=438&issue=4&spage=423 DB - PRIME DP - Unbound Medicine ER -