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Bioactive compounds from Iostephane heterophylla (Asteraceae).
Nat Prod Lett. 2001; 15(2):93-101.NP

Abstract

The novel bisabolene sesquiterpenes 3-6, were isolated from Iostephane heterophylla, using bioguided fractionation. The new compounds were determined to be (12R/12S)-12,13-epoxy-xanthorrhizols (3,4) and (12R/12S)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). The stereochemistry at C-12 of 5 was deduced using the modified Mosher experiment. Some of the isolated compounds elicited activity against gram positive and gram negative bacteria, levadura and dermatophytes.

Authors+Show Affiliations

Aguilar MI
Departamento de Farmacia, Conjunto E de la Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México, D.F.
Delgado G
No affiliation info available
Hernández ML
No affiliation info available
Villarreal ML
No affiliation info available

MeSH

Anti-Bacterial AgentsAnti-Infective AgentsAsteraceaeCandida albicansChromatography, High Pressure LiquidEnterococcus faecalisGlycosidesMexicoMicrosporumMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant RootsPlants, MedicinalProteus mirabilisSesquiterpenesSpectrophotometry, UltravioletStaphylococcus aureusStereoisomerismStructure-Activity RelationshipTrichophyton

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11561451

Citation

Aguilar, M I., et al. "Bioactive Compounds From Iostephane Heterophylla (Asteraceae)." Natural Product Letters, vol. 15, no. 2, 2001, pp. 93-101.
Aguilar MI, Delgado G, Hernández ML, et al. Bioactive compounds from Iostephane heterophylla (Asteraceae). Nat Prod Lett. 2001;15(2):93-101.
Aguilar, M. I., Delgado, G., Hernández, M. L., & Villarreal, M. L. (2001). Bioactive compounds from Iostephane heterophylla (Asteraceae). Natural Product Letters, 15(2), 93-101.
Aguilar MI, et al. Bioactive Compounds From Iostephane Heterophylla (Asteraceae). Nat Prod Lett. 2001;15(2):93-101. PubMed PMID: 11561451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive compounds from Iostephane heterophylla (Asteraceae). AU - Aguilar,M I, AU - Delgado,G, AU - Hernández,M L, AU - Villarreal,M L, PY - 2001/9/20/pubmed PY - 2002/2/6/medline PY - 2001/9/20/entrez SP - 93 EP - 101 JF - Natural product letters JO - Nat Prod Lett VL - 15 IS - 2 N2 - The novel bisabolene sesquiterpenes 3-6, were isolated from Iostephane heterophylla, using bioguided fractionation. The new compounds were determined to be (12R/12S)-12,13-epoxy-xanthorrhizols (3,4) and (12R/12S)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). The stereochemistry at C-12 of 5 was deduced using the modified Mosher experiment. Some of the isolated compounds elicited activity against gram positive and gram negative bacteria, levadura and dermatophytes. SN - 1057-5634 UR - https://www.unboundmedicine.com/medline/citation/11561451/Bioactive_compounds_from_Iostephane_heterophylla__Asteraceae__ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:11561451 DB - PRIME DP - Unbound Medicine ER -