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Gastrin determinations in symptomatic patients before and after standard ulcer operations.
Arch Surg. 1975 Aug; 110(8):875-8.AS

Abstract

Whereas 67 patients with duodenal ulcer had fasting and 30-minute postprandial mean serum gastrin levels not substantially different from 32 normal subjects, they had substantially higher fasting and histamine-stimulated gastric acid secretion. The increased acid secretion found in patients with duodenal ulcer is not caused by increased serum gastrin levels. Ten patients with recurrent ulcer, after incomplete vagotomy and gastric resection, had high gastric acid secretion and normal serum gastrin levels. Three patients with recurrent ulcer following complete vagotomy and gastric resection, but with retained antrum, had both high gastric acid secretion and high fasting and postprandial secrum gastrin levels. Three patients with Zollinger-Ellison tumors had even higher basal acid outputs and serum gastrin levels. The combination of basic gastric acid secretory studies and serum gastrin determinations may identify three causes of recurrent ulcer: incomplete vagotomy, retained antrum, and Zollinger-Ellison tumor.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1156153

Citation

Stremple, J F., and D W. Elliott. "Gastrin Determinations in Symptomatic Patients Before and After Standard Ulcer Operations." Archives of Surgery (Chicago, Ill. : 1960), vol. 110, no. 8, 1975, pp. 875-8.
Stremple JF, Elliott DW. Gastrin determinations in symptomatic patients before and after standard ulcer operations. Arch Surg. 1975;110(8):875-8.
Stremple, J. F., & Elliott, D. W. (1975). Gastrin determinations in symptomatic patients before and after standard ulcer operations. Archives of Surgery (Chicago, Ill. : 1960), 110(8), 875-8.
Stremple JF, Elliott DW. Gastrin Determinations in Symptomatic Patients Before and After Standard Ulcer Operations. Arch Surg. 1975;110(8):875-8. PubMed PMID: 1156153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrin determinations in symptomatic patients before and after standard ulcer operations. AU - Stremple,J F, AU - Elliott,D W, PY - 1975/8/1/pubmed PY - 1975/8/1/medline PY - 1975/8/1/entrez SP - 875 EP - 8 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 110 IS - 8 N2 - Whereas 67 patients with duodenal ulcer had fasting and 30-minute postprandial mean serum gastrin levels not substantially different from 32 normal subjects, they had substantially higher fasting and histamine-stimulated gastric acid secretion. The increased acid secretion found in patients with duodenal ulcer is not caused by increased serum gastrin levels. Ten patients with recurrent ulcer, after incomplete vagotomy and gastric resection, had high gastric acid secretion and normal serum gastrin levels. Three patients with recurrent ulcer following complete vagotomy and gastric resection, but with retained antrum, had both high gastric acid secretion and high fasting and postprandial secrum gastrin levels. Three patients with Zollinger-Ellison tumors had even higher basal acid outputs and serum gastrin levels. The combination of basic gastric acid secretory studies and serum gastrin determinations may identify three causes of recurrent ulcer: incomplete vagotomy, retained antrum, and Zollinger-Ellison tumor. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/1156153/Gastrin_determinations_in_symptomatic_patients_before_and_after_standard_ulcer_operations_ L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/vol/110/pg/875 DB - PRIME DP - Unbound Medicine ER -