Tags

Type your tag names separated by a space and hit enter

Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine.
Aliment Pharmacol Ther. 2001 Oct; 15(10):1579-83.AP

Abstract

BACKGROUND

Histamine H2-receptor antagonists are available over the counter for the treatment of heartburn.

AIM

To compare the effects of low doses of ranitidine and famotidine on intragastric acidity in a three-way crossover study.

METHODS

Healthy subjects (12 male, 12 female) were dosed on three occasions with single oral doses of placebo, ranitidine, 75 mg, and famotidine, 10 mg, 1 h after lunch. The pH of gastric aspirates was then measured for 20 h. Subjects ate standard meals and snacks. Analysis of variance was used to determine the statistical significance of differences in acidity (mmol/L) during the day (12.30-22.30 hours) and night (22.30-08.30 hours).

RESULTS

Ranitidine and famotidine were superior (P < 0.05) to placebo in decreasing acidity for daytime and night-time intervals. There were no significant differences in mean gastric acidity between ranitidine and famotidine during the daytime (11.37 mmol/L vs. 13.42 mmol/L, respectively) and night-time (23.57 mmol/L vs. 24.74 mmol/L, respectively). Intragastric acidity after ranitidine was significantly lower than that after famotidine in the first 2.5-h period following dosing (4.32 mmol/L vs. 9.28 mmol/L; P < 0.05).

CONCLUSIONS

Lunchtime doses of ranitidine and famotidine decreased acidity during day- and night-time periods. The effect of ranitidine was significantly greater for the first 2.5 h after dosing.

Authors+Show Affiliations

Centre for Gastroenterology, Royal Free and University College Medical School, Rowland HillStreet, London NW3 2PF, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11563997

Citation

Hamilton, M I., et al. "Control of Intragastric Acidity With Over-the-counter Doses of Ranitidine or Famotidine." Alimentary Pharmacology & Therapeutics, vol. 15, no. 10, 2001, pp. 1579-83.
Hamilton MI, Sercombe J, Pounder RE. Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine. Aliment Pharmacol Ther. 2001;15(10):1579-83.
Hamilton, M. I., Sercombe, J., & Pounder, R. E. (2001). Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine. Alimentary Pharmacology & Therapeutics, 15(10), 1579-83.
Hamilton MI, Sercombe J, Pounder RE. Control of Intragastric Acidity With Over-the-counter Doses of Ranitidine or Famotidine. Aliment Pharmacol Ther. 2001;15(10):1579-83. PubMed PMID: 11563997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine. AU - Hamilton,M I, AU - Sercombe,J, AU - Pounder,R E, PY - 2001/9/21/pubmed PY - 2002/6/29/medline PY - 2001/9/21/entrez SP - 1579 EP - 83 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 15 IS - 10 N2 - BACKGROUND: Histamine H2-receptor antagonists are available over the counter for the treatment of heartburn. AIM: To compare the effects of low doses of ranitidine and famotidine on intragastric acidity in a three-way crossover study. METHODS: Healthy subjects (12 male, 12 female) were dosed on three occasions with single oral doses of placebo, ranitidine, 75 mg, and famotidine, 10 mg, 1 h after lunch. The pH of gastric aspirates was then measured for 20 h. Subjects ate standard meals and snacks. Analysis of variance was used to determine the statistical significance of differences in acidity (mmol/L) during the day (12.30-22.30 hours) and night (22.30-08.30 hours). RESULTS: Ranitidine and famotidine were superior (P < 0.05) to placebo in decreasing acidity for daytime and night-time intervals. There were no significant differences in mean gastric acidity between ranitidine and famotidine during the daytime (11.37 mmol/L vs. 13.42 mmol/L, respectively) and night-time (23.57 mmol/L vs. 24.74 mmol/L, respectively). Intragastric acidity after ranitidine was significantly lower than that after famotidine in the first 2.5-h period following dosing (4.32 mmol/L vs. 9.28 mmol/L; P < 0.05). CONCLUSIONS: Lunchtime doses of ranitidine and famotidine decreased acidity during day- and night-time periods. The effect of ranitidine was significantly greater for the first 2.5 h after dosing. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/11563997/Control_of_intragastric_acidity_with_over_the_counter_doses_of_ranitidine_or_famotidine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2001&amp;volume=15&amp;issue=10&amp;spage=1579 DB - PRIME DP - Unbound Medicine ER -