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Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats.

Abstract

Zinc has a wide spectrum of biological activities and its deficiency has been related to various dysfunctions and alterations of normal cell metabolism. The effects of adequate Zn level (38 mg/kg diet, control) and two low levels that create Zn deficiencies (19 mg/kg diet, 1/2 of control and 3.8 mg/kg diet, 1/10 of control) were investigated in growing male and female rats for 10 weeks. This allowed for evaluation of the effects these Zn levels may have on body weight gain, specific organ weights, blood parameters, and serum concentrations of Zn, Cu and Fe. Rats fed Zn-deficient diets gained less (P<0.05) than the control groups. There was increase (P<0.05) in liver and spleen weights, and a decrease (P<0.05) in testes weight. However, brain, kidney, heart, and lung weights were not affected (P<0.05). Hematological parameters that were decreased (P<0.05) by Zn deficiency included hemoglobin (Hb), total erythrocyte count (TEC) and packed cell volume (PCV) with the magnitude being dose-dependent. Serum concentrations of total protein, globulin, glucose, and high density lipoprotein (HDL) also decreased (P<0.05) in a dose-dependent manner. Zn deficiency increased (P<0.05) total leukocyte count (TLC) and concentrations of serum albumin, total lipids, cholesterol, triglycerides and low density lipoprotein (LDL) in a dose-dependent manner. Serum concentrations of urea and creatinine were, however, not affected (P<0.05) by zinc deficiency. Zn-deficient rats had lower serum concentrations of Zn, Cu and Fe. These results showed that Zn deficiency has negative effects on growth rate, specific organ weights, hematological parameters, and serum levels of Zn, Cu and Fe, especially in rats fed the lowest Zn level.

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  • Authors+Show Affiliations

    ,

    Department of Home Economics, Faculty of Agriculture, El-Shatby, Alexandria University, Alexandria, Egypt.

    ,

    Source

    Toxicology 167:2 2001 Oct 15 pg 163-70

    MeSH

    Albumins
    Animals
    Blood Cell Count
    Blood Proteins
    Clinical Chemistry Tests
    Copper
    Creatinine
    Diet
    Dose-Response Relationship, Drug
    Female
    Globulins
    Iron
    Male
    Organ Size
    Rats
    Urea
    Weight Gain
    Zinc

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11567779

    Citation

    El Hendy, H A., et al. "Effect of Dietary Zinc Deficiency On Hematological and Biochemical Parameters and Concentrations of Zinc, Copper, and Iron in Growing Rats." Toxicology, vol. 167, no. 2, 2001, pp. 163-70.
    El Hendy HA, Yousef MI, Abo El-Naga NI. Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats. Toxicology. 2001;167(2):163-70.
    El Hendy, H. A., Yousef, M. I., & Abo El-Naga, N. I. (2001). Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats. Toxicology, 167(2), pp. 163-70.
    El Hendy HA, Yousef MI, Abo El-Naga NI. Effect of Dietary Zinc Deficiency On Hematological and Biochemical Parameters and Concentrations of Zinc, Copper, and Iron in Growing Rats. Toxicology. 2001 Oct 15;167(2):163-70. PubMed PMID: 11567779.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats. AU - El Hendy,H A, AU - Yousef,M I, AU - Abo El-Naga,N I, PY - 2001/9/25/pubmed PY - 2001/11/3/medline PY - 2001/9/25/entrez SP - 163 EP - 70 JF - Toxicology JO - Toxicology VL - 167 IS - 2 N2 - Zinc has a wide spectrum of biological activities and its deficiency has been related to various dysfunctions and alterations of normal cell metabolism. The effects of adequate Zn level (38 mg/kg diet, control) and two low levels that create Zn deficiencies (19 mg/kg diet, 1/2 of control and 3.8 mg/kg diet, 1/10 of control) were investigated in growing male and female rats for 10 weeks. This allowed for evaluation of the effects these Zn levels may have on body weight gain, specific organ weights, blood parameters, and serum concentrations of Zn, Cu and Fe. Rats fed Zn-deficient diets gained less (P<0.05) than the control groups. There was increase (P<0.05) in liver and spleen weights, and a decrease (P<0.05) in testes weight. However, brain, kidney, heart, and lung weights were not affected (P<0.05). Hematological parameters that were decreased (P<0.05) by Zn deficiency included hemoglobin (Hb), total erythrocyte count (TEC) and packed cell volume (PCV) with the magnitude being dose-dependent. Serum concentrations of total protein, globulin, glucose, and high density lipoprotein (HDL) also decreased (P<0.05) in a dose-dependent manner. Zn deficiency increased (P<0.05) total leukocyte count (TLC) and concentrations of serum albumin, total lipids, cholesterol, triglycerides and low density lipoprotein (LDL) in a dose-dependent manner. Serum concentrations of urea and creatinine were, however, not affected (P<0.05) by zinc deficiency. Zn-deficient rats had lower serum concentrations of Zn, Cu and Fe. These results showed that Zn deficiency has negative effects on growth rate, specific organ weights, hematological parameters, and serum levels of Zn, Cu and Fe, especially in rats fed the lowest Zn level. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/11567779/Effect_of_dietary_zinc_deficiency_on_hematological_and_biochemical_parameters_and_concentrations_of_zinc_copper_and_iron_in_growing_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300483X01003730 DB - PRIME DP - Unbound Medicine ER -