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Detection of cocaine and its metabolites in breast milk.
J Forensic Sci. 2001 Sep; 46(5):1221-3.JF

Abstract

A method was developed for measuring cocaine and its metabolites, benzoylecgonine, ecgonine methyl ester, norcocaine, ecgonine ethyl ester, cocaethylene, and m-hydroxybenzoylecgonine, in breast milk by gas chromatography/mass spectrometry. Limits of detection for this method ranged from 2.5 to 10 ng/mL, and limits of quantitation ranged from 5 to 50 ng/mL. For each of the compounds measured by this method, linear response was demonstrated to 750 ng/mL. Breast milk was collected from 11 mothers who admitted to drug use during pregnancy and ten drug-free volunteers serving as control subjects. Cocaine was detected in six of the specimens obtained from drug-exposed subjects, and in none of the drug-free control subjects. In breast milk specimens where cocaine and one or more of its metabolites were detected, the concentration of parent compound was greater than any of the metabolites. The highest cocaine concentration found was over 12 microg/mL. Breast-fed infants of cocaine abusing mothers may be exposed to significant amounts of drug orally.

Authors+Show Affiliations

Department of Pathology, University of Florida College of Medicine, Gainesville, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11569568

Citation

Winecker, R E., et al. "Detection of Cocaine and Its Metabolites in Breast Milk." Journal of Forensic Sciences, vol. 46, no. 5, 2001, pp. 1221-3.
Winecker RE, Goldberger BA, Tebbett IR, et al. Detection of cocaine and its metabolites in breast milk. J Forensic Sci. 2001;46(5):1221-3.
Winecker, R. E., Goldberger, B. A., Tebbett, I. R., Behnke, M., Eyler, F. D., Karlix, J. L., Wobie, K., Conlon, M., Phillips, D., & Bertholf, R. L. (2001). Detection of cocaine and its metabolites in breast milk. Journal of Forensic Sciences, 46(5), 1221-3.
Winecker RE, et al. Detection of Cocaine and Its Metabolites in Breast Milk. J Forensic Sci. 2001;46(5):1221-3. PubMed PMID: 11569568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of cocaine and its metabolites in breast milk. AU - Winecker,R E, AU - Goldberger,B A, AU - Tebbett,I R, AU - Behnke,M, AU - Eyler,F D, AU - Karlix,J L, AU - Wobie,K, AU - Conlon,M, AU - Phillips,D, AU - Bertholf,R L, PY - 2001/9/25/pubmed PY - 2001/10/12/medline PY - 2001/9/25/entrez SP - 1221 EP - 3 JF - Journal of forensic sciences JO - J Forensic Sci VL - 46 IS - 5 N2 - A method was developed for measuring cocaine and its metabolites, benzoylecgonine, ecgonine methyl ester, norcocaine, ecgonine ethyl ester, cocaethylene, and m-hydroxybenzoylecgonine, in breast milk by gas chromatography/mass spectrometry. Limits of detection for this method ranged from 2.5 to 10 ng/mL, and limits of quantitation ranged from 5 to 50 ng/mL. For each of the compounds measured by this method, linear response was demonstrated to 750 ng/mL. Breast milk was collected from 11 mothers who admitted to drug use during pregnancy and ten drug-free volunteers serving as control subjects. Cocaine was detected in six of the specimens obtained from drug-exposed subjects, and in none of the drug-free control subjects. In breast milk specimens where cocaine and one or more of its metabolites were detected, the concentration of parent compound was greater than any of the metabolites. The highest cocaine concentration found was over 12 microg/mL. Breast-fed infants of cocaine abusing mothers may be exposed to significant amounts of drug orally. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/11569568/Detection_of_cocaine_and_its_metabolites_in_breast_milk_ L2 - https://medlineplus.gov/cocaine.html DB - PRIME DP - Unbound Medicine ER -