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Age-Related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats.
Jpn J Pharmacol. 2001 Aug; 86(4):448-50.JJ

Abstract

Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11569619

Citation

Yamaga, N, et al. "Age-Related Decrease in Calcitonin Gene-related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats." Japanese Journal of Pharmacology, vol. 86, no. 4, 2001, pp. 448-50.
Yamaga N, Kawasaki H, Inaizumi K, et al. Age-Related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats. Jpn J Pharmacol. 2001;86(4):448-50.
Yamaga, N., Kawasaki, H., Inaizumi, K., Shimizu, M., Nakamura, A., & Kurosaki, Y. (2001). Age-Related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats. Japanese Journal of Pharmacology, 86(4), 448-50.
Yamaga N, et al. Age-Related Decrease in Calcitonin Gene-related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats. Jpn J Pharmacol. 2001;86(4):448-50. PubMed PMID: 11569619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-Related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats. AU - Yamaga,N, AU - Kawasaki,H, AU - Inaizumi,K, AU - Shimizu,M, AU - Nakamura,A, AU - Kurosaki,Y, PY - 2001/9/25/pubmed PY - 2002/2/23/medline PY - 2001/9/25/entrez SP - 448 EP - 50 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 86 IS - 4 N2 - Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/11569619/Age_Related_decrease_in_calcitonin_gene_related_peptide_mRNA_in_the_dorsal_root_ganglia_of_spontaneously_hypertensive_rats_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/jjp/86.448?from=PubMed DB - PRIME DP - Unbound Medicine ER -